The Space Shuttle was a partially reusable low Earth orbital spacecraft system operated by NASA (the National Aeronautics and Space Administration). Its official program name was Space Transportation System (STS), taken from a 1969 plan for a system of reusable spacecraft of which it was the only item funded for development.^[1] Operational missions launched numerous satellites, conducted science experiments in orbit, and participated in construction and servicing of the International Space Station (ISS). The first of four orbital test flights occurred in 1981, leading to operational flights beginning in 1982.

From 1981 to 2011 a total of 135 missions were flown, all launched from Kennedy Space Center (KSC) in Florida. During that time period the fleet logged 1,322 days, 19 hours, 21 minutes and 23 seconds of flight time.^[2] The longest orbital flight of the Shuttle was STS-80 at 17 days 15 hours, while the shortest flight was STS-51-L at one minute 13 seconds when the Space Shuttle Challenger broke apart during launch. The cold morning shrunk an O-Ring on the right Solid Rocket Booster causing the external fuel tank to explode. The shuttles docked with Russian space station Mir nine times and visited the ISS thirty-seven times. The highest altitude (apogee) achieved by the shuttle was 386 mi (621 km) when deploying the Hubble Space Telescope.^[3] The program flew a total of 355 people representing 16 countries, and with 852 total shuttle fliers.^[4] The Kennedy Space Center served as the landing site for 78 missions, while 54 missions landed at Edwards Air Force Base in California and one mission landed at White Sands, New Mexico.^[5]

The first orbiter built, Enterprise, was used for atmospheric flight tests (ALT) but future plans to upgrade it to orbital capability were ultimately canceled. Four fully operational orbiters were initially built: Columbia, Challenger, Discovery, and Atlantis. Challenger and Columbia were destroyed in mission accidents in 1986 and 2003 respectively, killing a total of fourteen astronauts. A fifth operational orbiter, Endeavour, was built in 1991 to replace Challenger. The Space Shuttle was retired from service upon the conclusion of STS-135 by Atlantis on 21 July 2011.^[6]

The U.S. Space Shuttle program was officially referred to as the Space Transportation System (STS). Specific shuttle missions were therefore designated with the prefix "STS".^[2] Initially, the launches were given sequential numbers indicating order of launch, such as STS-7. Subsequent to the Apollo 13 mishap, due to Administrator of NASA James M. Beggs's triskaidekaphobia and consequent unwillingness to number a forthcoming flight as STS-13,^{[7][8][9][10]} beginning in 1984, each mission was assigned a code, such as STS-41-B, with the first digit (or pair of digits for years 1990 and beyond) indicating the federal fiscal year offset into the program (so 41-B was scheduled for FY 1984, 51-A thru 51-L originally for FY 1985, and the third flight in FY 1995 would have been named 151-C), the second digit indicating the launch site (1 was Kennedy Space Center and 2 was Space Launch Complex 6 at Vandenberg Air Force Base, although Vandenberg was never used), and the letter indicating scheduling sequence.^[11] These codes were assigned when the launches were initially scheduled and were not changed as missions were delayed or rescheduled.^[6] The codes were adopted from STS-41-B through STS-51-L (although the highest code used was actually STS-61-C), and the sequential numbers were used internally at NASA on all processing paperwork.

After the Challenger disaster, NASA returned to using a sequential numbering system, with the number counting from the beginning of the STS program. Unlike the initial system, however, the numbers were assigned based on the initial mission schedule, and did not always reflect actual launch order. This numbering scheme started at 26, with the first flight as STS-26R—the R suffix stood for "reflight" to disambiguate from prior missions. The suffix was used for two years through STS-33R, then the R was dropped.^[6] As a result of the changes in systems, flights under different numbering systems could have the same number with one having a letter appended, e.g. flight STS-51 (a mission carried out by Discovery in 1993) was many years after STS-51-A (Discovery's second flight in 1984).^[6] It wasn't until STS-127 in 2009 where the flight numbering system returned to a standard and consistent order.

• International Space Station construction
• List of Buran missions
• List of human spaceflights
• List of human spaceflights to the International Space Station
• List of Soyuz missions
• List of Space Shuttle crews
• List of Space Shuttle rollbacks