Notable Syro-Malabar Catholics include:

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• Parambil Chandy Malpan (Malpan 1663–87)
• Joseph Kariattil (Appointed in 1782)
• Paremmakkal Thoma Kathanar (Appointed in 1786)
• Abraham Pandari (Poulose) (Appointed in 1798)
• Palackal Thoma Malpan (1780–1841)
• Kuriakose Elias Chavara (1805–71)
• Nidhiry Mani Kathanar (1842–1904)
• Aloysius Pazheparambil (1847–1919)
• Thomas Kurialachery (1873–1925)
• Augustine Kandathil (1874–1956), first head of the Syro-Malabar Church after the restoration of hierarchy

• Varghese Payyappilly Palakkappilly (1876–1929)
• Joseph C. Panjikaran (1888-1949)
• Thevarparampil Kunjachan (Kunjachan) (1891–1973)
• Alphonsa of India (1910–46)
• Euphrasia Eluvathingal (1877-1952)
• Joseph Parecattil (1912–87)
• Abel Periyappuram (1920–2001), monk, journalist, and lyricist, and the founder of Kalabhavan
• Antony Padiyara (1921–2000)
• Varkey Vithayathil (1927–2011)
• Abraham Kattumana (1944–1995)

• Thoma of Villarvattom (c. 15th century CE): The only Christian King in the history of the Indian sub-continent.
• Thachil Matthoo Tharakan
• C. J. Varkey, Chunkath, Minister of Madras Presidency (1939).^[1]
• A. J. John, Anaparambil (1893–1957), Chief Minister of Travancore-Cochin (1951–53) and Governor of Madras.^[1]
• P. T. Chacko, Pullolil, Member of Indian Constituent Assembly from Travancore (1949–50), and Home Minister of Kerala (1960–64).^[1]
• K. K. Mathew, former supreme court judge

• Paremmakkal Thoma Kathanar - Author of the first travelogue in an Indian language (1778)^[2]
• P. C. Devassia, author, literary translator poet, and composer of Christian poetry in Sanskrit
• Mathew Ulakamthara, author of epic Christu Gadha and recipient of Sabha Rathnam, the highest honor of the Syro-Malabar Church.^[3]
• George Menachery, a scholar, historian and Papal Dignitary.
• Pius Malekandathil, a historian, author and scholar
• Santhosh George Kulangara - entrepreneur and explorer^[4]
• Asin Thottumkal- Former Indian actress.