There have been 32 vice presidents of Colombia since the position was first created in 1819. The position has been created interspersed in the different constitutions of the country.

The vice president is the first person in the line of presidential succession and assumes the presidency if the president dies, resigns, or is impeached and removed from office. A single vice president has ascended to the presidency in this way: only one through the death of the president (Miguel Antonio Caro) Vice presidents have wielded the latter power to varying degrees over the years.

Under the Colombian Constitution of 1991, the Vice President of Colombia is the first in the Presidential line of Succession of the Republic of Colombia. In absence of both the president and the vice president, Article 203 of the Constitution of 1991 establishes that the presidential office will be assumed by a minister in the order of precedence established by law. The assuming minister has to be a member of the same party or movement the original president belonged to, and will exercise the presidency until the Congress, within the 30 days following the presidential vacancy, elects a new vice president who will assume the presidency.

• List of viceroys of New Granada
• List of presidential designates of Colombia
• List of presidents of Colombia