The following is a listing of fictional characters from the HBO series, The Wire. Note that some characters' allegiances or positions may have changed over time; and, although the series has ended, the placement below is generally meant to reflect their most recent situation. Also, some specific plot lines may be revealed in a character's description.

Law enforcement is an integral part of The Wire and characters in this field range from those enforcing the law at street level to those setting laws citywide.

Those involved in drug dealing and drug addicts alike are featured. Thieves and sex workers are also featured.

Stevedores, their families, and the criminal organization that is involved in the smuggling through the Baltimore docks are featured.

Both honest and corrupt state and city officials depicted in the series are included in this section.

Pupils, staff and employees in the school system are featured.

The fifth season features an examination of a fictionalized version of The Baltimore Sun and introduced several journalist characters.