The following is a list of companies based in San Francisco, California. Fortune 500 rankings are indicated in parentheses, based on the list of the Fortune 500 companies in 2008.

This article may require cleanup to meet Wikipedia's quality standards. (June 2011)

• Bank of America – relocated to Charlotte, North Carolina
• Bechtel - relocated to Reston, Virginia
• California State Automobile Association – relocated to Walnut Creek, California
• Charles Schwab Corporation - relocated to Westlake, Texas in 2019
• Chevron – relocated to San Ramon, California
• Core-Mark - relocated to Dallas, Texas in 2019
• Cost Plus World Market - relocated to Oakland
• Crocker Bank – purchased by Wells Fargo Bank
• Del Monte Foods - relocated to Walnut Creek, California
• Esprit – relocated to Ratingen, Germany and Hong Kong
• Excite@Home – purchased by Ask.com
• Flickr – acquired by Yahoo!
• Folgers Coffee – acquired by The J.M. Smucker Co.
• Gymboree - defunct
• Hambrecht & Quist, LLC – purchased by Chase Manhattan Bank, later folded into JP Morgan Securities following Chase's purchase of JPM
• Hearst Corporation – relocated to New York City
• Hills Brothers Coffee – purchased by Massimo Zanetti Beverage USA
• Link TV - merged with KCET in 2012
• McKesson Corp - relocated to Irving, Texas
• Montgomery Securities – purchased by NationsBank Corporation on June 30, 1997
• Pacific Telesis – acquired by SBC Communications, which became AT&T when it purchased AT&T Corporation
• Pacific Gas and Electric Company - moved to Oakland, California in 2022
• Palantir Technologies - relocated to Austin, Texas in 2021
• Patelco Credit Union - relocated to Dublin, California in 2018
• Pegasus Aviation Finance Company – acquired by AWAS
• Popchips - relocated to Playa Vista, California
• Robertson Stephens – closed by its parent company FleetBoston in July 2002
• Rolling Stone – relocated to New York City, New York
• The Sharper Image - relocated to Farmington Hills, Michigan
• Sega of America - relocated to Irvine, California in 2015
• SKYY Spirits - renamed Campari America after acquisition by Campari Group and relocated to New York City in 2018
• Six Apart – moved to Tokyo
• Southern Pacific – acquired by Union Pacific Railroad
• Sunset Magazine - relocated to Oakland, California
• Swensen's Ice Cream – acquired by International Franchise Corp (IFC) of Markham, Ontario, Canada
• Transamerica – purchased by Aegon
• Union Bank of California - relocated to New York City
• United Commercial Bank – acquired by East West Bank
• URS Corporation - acquired by AECOM in 2014

• List of companies based in the San Francisco Bay Area