This is a list of fiction set in Pittsburgh, Pennsylvania.

• Afterimage by Kathleen George
• All in Good Time^[1] by Carolyn Astfalk
• An American Childhood by Annie Dillard
• American Rust by Philipp Meyer
• Another Kind of Monday by William Coles
• The Autobiography of My Body by David Guy
• Blood on the Forge by William Attaway
• The Book of Jonas by Stephen Dau
• Burning Valley by Philip Bonosky
• Captains and Kings by Taylor Caldwell
• Christine by Stephen King
• Disquiet Heart by Randall Silvis
• Duffy's Rocks by Edward Fenton
• East Pittsburgh Downlow by Dave Newman
• Elfhome (series) by Wen Spencer
• Emily, Alone by Stewart O'Nan
• Fallen by Kathleen George
• Greenhorn on the Frontier by Ann Finlayson
• Ghosts of the Golden Triangle by Mord McGhee
• The Homewood Books by John Edgar Wideman
• Iron City by Lloyd L. Brown
• Ironblood (novel) by Mord McGhee
• The King's Orchard by Agnes Sligh Turnbull (1963)
• The Last Chicken in America by Ellen Litman
• The Leap Year Boy by Marc Simon (2013)^[2]
• Lethal Legacy by Gerald Myers
• A Little Girl in Old Pittsburg
• Looking For The General by Warren Miller
• The Man Who Liked Slow Tomatoes by K.C. Constantine
• The Memory Keeper's Daughter
• A Model World and Other Stories by Michael Chabon
• Monongahela Dusk by John Hoerr
• The Mysteries of Pittsburgh by Michael Chabon
• Ornamental Graces^[3] by Carolyn Astfalk
• Out of This Furnace by Thomas Bell
• The Perks of Being a Wallflower by Stephen Chbosky
• Remember the End by Agnes Sligh Turnbull (1938)
• Riot by William Trautmann
• Seducing Mr. Darcy by Gwyn Cready (2008)
• Sent for You Yesterday by John Edgar Wideman
• Settling Accounts: Drive to the East
• She Gets the Girl by Rachael Lippincott and Alyson Derrick
• Taken by Kathleen George
• The Tempering by Gloria Skurzynski
• Three Golden Rivers by Olive Price
• The Two Georges
• U.S.A. by John dos Passos
• Ukiah Oregon (series)
• Watch Your Mouth by Daniel Handler
• Wonder Boys by Michael Chabon

• Firestorm the Nuclear Man
• The Pitt
• Star Brand

• The Pittsburgh Cycle - In 2005, August Wilson completed a ten-play cycle, nine of which are set in Pittsburgh, chronicling the African-American experience in the 20th century. These are:
• 1900s - Gem of the Ocean (2003)
• 1910s - Joe Turner's Come and Gone (1984)
• 1920s - Ma Rainey's Black Bottom (1982) - set in Chicago
• 1930s - The Piano Lesson (1986) - Pulitzer Prize
• 1940s - Seven Guitars (1995)
• 1950s - Fences (1985) - Pulitzer Prize
• 1960s - Two Trains Running (1990)
• 1970s - Jitney (1982)
• 1980s - King Hedley II (2001)
• 1990s - Radio Golf (2005)

• "America", written by Paul Simon and performed by Simon & Garfunkel, includes the line "Kathy", I said, / As we boarded a Greyhound in Pittsburgh, / Michigan seems like a dream to me now."^[4]
• "Duquesne Whistle," which appears on the Bob Dylan album Tempest, was co-written by Dylan and Robert Hunter.^[5] The song describes a train ride through Pittsburgh. NPR's Ann Powers speculates that this may be the same train described in Dylan's "Lo and Behold".^[5]
• "A Good Man Is Hard to Find" by Bruce Springsteen describes "It's cloudy out in Pittsburgh / It's raining in Saigon / Snow's falling across the Michigan line."^[4]
• "I'm Not Dead (I'm in Pittsburgh)", which appears on the Frank Black album Fast Man Raider Man, was co-written by Black and Pittsburgher Reid Paley.^[4] It draws upon Pittsburgh's historical connection with the zombie genre.^[4]

"I finally found a place to call my own / a place where all good sinners can get stoned / I'll keep my holy vision, you keep your stupid pride / You said I couldn't make it on my own / But I'm not dead (I'm in Pittsburgh) / And now I can't get out of town / But I'm not dead (I'm in Pittsburgh) / They've got me all strung, come cut me down."

• "Life During Wartime," which appears on Talking Heads' Fear of Music and Stop Making Sense, asks the listener in a post-apocalyptic landscape, "Heard about Houston? Heard about Detroit? Heard about Pittsburgh, PA?"^[4] Long-time Talking Heads drummer Chris Frantz grew up in Pittsburgh.^[4]
• "Lo and Behold," which appears on The Basement Tapes by Bob Dylan and the Band, tells the story of the narrator recounting a train ride with "I come into Pittsburgh / At six-thirty flat / I found myself a vacant seat / An' I put down my hat."^[4]
• "Sweet Little Sixteen", by Chuck Berry, rhymes "Pittsburgh, P.A." with "Frisco Bay."^[4]
• "Six Days on the Road", written by Earl Green and Carl Montgomery, describes a trucker who says "Well, I pulled out of Pittsburgh", in describing life on the road.^[4]
• Pittsburgher Wiz Khalifa often mentions the city in his music.
• Pittsburgher Mac Miller often mentions his hometown in his music

• The Fallout 3 DLC "The Pitt" takes place in Pittsburgh
• The Last of Us