Mephitidae is a family of mammals in the order Carnivora, which comprises the skunks and stink badgers. A member of this family is called a mephitid. The skunks of the family are widespread across the Americas, while the stink badgers are in the Greater Sunda Islands of southeast Asia. Species inhabit a variety of habitats, though typically grassland, forest, and shrubland. Most mephitids are 20–50 cm (8–20 in) long, plus a 10–40 cm (4–16 in) tail, though the pygmy spotted skunk can be as small as 11 cm (4 in) plus a 7 cm (3 in) tail, and some striped skunks can be up to 82 cm (32 in) plus a 40 cm (16 in) tail. No estimates have been made for overall population sizes of any of the species, but two species are classified as vulnerable. Mephetids in general are not domesticated, though skunks are sometimes kept as pets.^[1]

The twelve species of Mephitidae are split into four genera: the monotypic Conepatus, hog-nosed skunks; Mephitis, skunks; Mydaus, stink badgers; and Spilogale, spotted skunks. Mephitidae was traditionally a clade within the Mustelidae family, with the stink badgers combined with other badgers within the Melinae genus, but more recent genetic evidence resulted in the consensus to separate Mephitidae into its own family.^[2] Extinct species have also been placed into all of the extant genera besides Mydaus, as well as 9 extinct genera; 26 extinct Mephitidae species have been found, though due to ongoing research and discoveries the exact number and categorization is not fixed.

Conservation status codes listed follow the International Union for Conservation of Nature (IUCN) Red List of Threatened Species. Range maps are provided wherever possible; if a range map is not available, a description of the mephetid's range is provided. Ranges are based on the IUCN Red List for that species unless otherwise noted. All extinct species or subspecies listed alongside extant species went extinct after 1500 CE, and are indicated by a dagger symbol "†". Population figures are rounded to the nearest hundred.

The family Mephitidae consists of twelve extant species belonging to four genera and divided into dozens of extant subspecies. It is not divided into subfamilies. This does not include hybrid species or extinct prehistoric species.

• Genus Conepatus (hog-nosed skunks): four species
• Genus Mephitis (skunks): two species
• Genus Mydaus: (stink badgers): two species
• Genus Spilogale: (spotted skunks): four species

The following classification is based on the taxonomy described by Mammal Species of the World (2005), with augmentation by generally accepted proposals made since using molecular phylogenetic analysis.