Long-chain-fatty-acid-(acyl-carrier-protein)_ligase

Long-chain-fatty-acid—(acyl-carrier-protein) ligase

Long-chain-fatty-acid—(acyl-carrier-protein) ligase

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In enzymology, a long-chain-fatty-acid—[acyl-carrier-protein] ligase (EC 6.2.1.20) is an enzyme that catalyzes the chemical reaction

ATP + an acid + [acyl-carrier-protein] AMP + diphosphate + acyl-[acyl-carrier-protein]
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The 3 substrates of this enzyme are ATP, acid, and acyl-carrier-protein, whereas its 3 products are AMP, diphosphate, and [[acyl-[acyl-carrier-protein]]].

This enzyme belongs to the family of ligases, specifically those forming carbon-sulfur bonds as acid-thiol ligases. The systematic name of this enzyme class is long-chain-fatty-acid:[acyl-carrier-protein] ligase (AMP-forming). Other names in common use include acyl-[acyl-carrier-protein] synthetase, acyl-[acyl carrier protein] synthetase, acyl-ACP synthetase, acyl-[acyl-carrier-protein]synthetase, stearoyl-ACP synthetase, and acyl-acyl carrier protein synthetase. This enzyme participates in fatty acid metabolism.

References

    • Ray TK, Cronan JE (1976). "Activation of long chain fatty acids with acyl carrier protein: demonstration of a new enzyme, acyl-acyl carrier protein synthetase, in Escherichia coli". Proc. Natl. Acad. Sci. U.S.A. 73 (12): 4374–8. doi:10.1073/pnas.73.12.4374. PMC 431460. PMID 794875.


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