Lupin heads to the Mediterranean island of Colcaca in pursuit of a box said to contain a draft of Ernest Hemingway's final, unfinished novel which supposedly describes the author's last journey and his discovery of great riches. Unfortunately, the island has been under siege by would-be treasure hunters for ten years. These are divided into two factions, led by self-appointed president Carlos and his rival, the warlord Consano. They do not take kindly to intruders, and have turned the island into one big battle zone.

Lupin discovers that Goemon and Jigen have, for their own reasons, teamed up with respectively Carlos and Consano, who intend to use them as their trump cards in battle. The arrival of gun runner Marcess and his beautiful, busty secretary could further inflame the situation.

Lupin decides to participate in a classic car race because he wants the first prize – the dictionary that once belonged to Napoleon. It may not contain the word "impossible", but it DOES contain directions to Lupin's grandfather's treasure – a treasure literally sought by the whole world, since the G7 nations want it in order to rebuild the world economy after the Gulf war. No one knows where or what it is, but it's said to be worth trillions of dollars – and Lupin, being the rightful heir, is assumed to be the one to ask.

Inspector Zenigata has been taken off the Lupin case due to his inability to capture him, and been replaced with a much more ruthless agent, Keith, who will gladly take Lupin dead if he cannot take him alive. This does not sit well with Zenigata, who has always had a respect for Lupin. He goes against his orders and gives this information to the master thief, giving Lupin and his gang the edge they need to stay alive.

Lupin, Jigen, and Fujiko are contacted by a Hong Kong gangster, Chen Zhenzhong, to steal a metal statue of a dragon lost when the Titanic sank. Lupin refuses to work for Chen, but retains an interest in the statue; his grandfather Arsène Lupin attempted and failed to steal it on that fateful voyage. The three decide to go after it on their own.

Don Dolune, a former associate of Lupin, gives Lupin half of a diamond called the Twilight. By finding the other half of the diamond, it will allow Lupin to access a fantastic treasure. Lupin and Jigen travel to Morocco with some interference from Inspector Zenigata.

Lupin investigates the news of a fake version of one of his trademark calling cards during a high-class party. A group of assassins, the Tarantula, crash the party and murder the host. Zenigata, investigating the card, chases Lupin but ends up shot and injured by a silver Walther P38. Lupin, catching a glimpse of the familiar gun, is determined to avenge not only Zenigata, but an episode of his past.

Lupin attempts and fails to steal a valuable set of Japanese photographic plates. The rightful owner of the plates, Michael Suzuki, is a multimillionaire who is preparing to open a huge water park in Tokyo. Lupin attempts to enlist the help of his steadfast comrades Jigen and Goemon but find them less than reliable; Jigen is suffering from a toothache that throws off his legendary aim, and Goemon has shamefully had his sword, Zantetsuken, stolen by a woman and given to Suzuki to display in his art collection. The group works on a plan with Fujiko to get both the plates and Zantetsuken.

During a romantic dinner with Lupin, Fujiko tells him about the Columbus Files, information that leads to a legendary treasure called the Columbus Egg. Before she can let Lupin in on the information, the rascally Nazaroff and his men attack. Chasing the two through the woods, Lupin and Fujiko find themselves cornered and hanging off of a cliff. Lupin cannot save Fujiko, who plummets to the ground below when a bullet severs the rope.

Lupin tries to acquire a quite plain ring at an auction, but is outbid by one dollar. Thus thwarted, he decides to steal it instead, and enlists the help of Jigen and Goemon. Cynthia, head of the Bank of the World, is the auction winner and their target. The ring is the key to locating a legendary brooch – Lupin's true objective. The robbery goes well until the getaway, when Lupin is shot out of a helicopter, falling towards his death. His comrades bury him and swears to finish what he started, and Inspector Zenigata resigns in grief.

Jigen is asked by a reporter to tell the story of how he met Lupin and the rest of the gang. He tells about the time he was hired by a millionaire named Galves to help guard the Clam of Hermes, a green cylinder made of unbreakable metal. The cylinder contained instructions on how to forge a metal similar to the one that composed it. The Clam has also gained the attentions of both Lupin, a fellow thief named Brad, and Brad's partner, Fujiko.

Brad manages to steal the Clam, but is murdered by Galves' henchman, Shade. Lupin and Fujiko now have possession of it, but no means to open it. Meanwhile, Inspector Zenigata has been dispatched by the Japanese police to hunt down and arrest Fujiko. He is paired with George McFly, an American detective who is his only resource. And on the other side of the world, Goemon is seeking a sword worthy of his skills.

The last will of master thief Mark Williams is for his old friend Lupin to return several famous objects to their rightful places, including the Bocca della Verità, a coffee maker from the first bottega da caffe in the Plaza San Marco, the speedboat/hovercraft gondola that James Bond used in the movie Moonraker, original can-can dresses from the Moulin Rouge, a car custom-made for the king of a Middle East country – which is actually a Mercedes-Benz 300SLR, and lastly The Little Mermaid statue in Copenhagen, Denmark. All of which Mark stole in his lifetime.

Doing so within a certain time limit will reveal to Lupin the location of the Trick Diamond, a jewel thought to be worthless because its only ability is to catch and retain light. Lupin, however, is certain that the stone holds more than meets the eye, as it is connected with both the Tunguska incident and the construction of La Sagrada Família in Barcelona.

After another daring heist, Lupin finds himself stolen; he is kidnapped by the crime lord Malchovich, and is forced to agree to steal the infamous 'Bull's Eye' jewel – or Fujiko will be killed by a bomb strapped around her neck. However, Lupin's progress is hindered by a young woman named Becky, who is out to prove herself by outdoing him in the field of thievery. She turns out to be the daughter of Cat, Lupin's first partner in crime...and her father's identity is anyone's guess.

Rebecca Rossellini has been kidnapped! Born to a prominent family of the Republic of San Marino, the young CEO of the Rossellini conglomerate operates the largest hotel chain in Italy. Rebecca is surrounded by no shortage of celebrity gossip. However, an enthusiastic fan named Pietro stages a kidnapping and train robbery.

In fact, a mysterious man is pulling the strings behind the scenes. He calls himself the Masked Earl, and before Rebecca was kidnapped he issued a challenge to Lupin, suggesting a contest: to see who can first obtain the famous inheritance of the Count of Cagliostro. The paths of British MI-6 Agent Nyx, Italian Police Chief Sergio, paparazzo Salo chasing Rebecca, and the Count's descendant Earl Gaspare all cross. Who really is the Masked Earl? And will Lupin be able to overcome the trap set by the Masked Earl?