Lusignan (French pronunciation: [lyziɲɑ̃]) is a commune in the Vienne department in the Nouvelle-Aquitaine region in western France. It lies 25 km southwest of Poitiers. The inhabitants are called Mélusins and Mélusines.

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Lusignan
Commune
A general view of Lusignan
Coat of arms
Location of Lusignan
Lusignan Show map of France Lusignan Show map of Nouvelle-Aquitaine
Coordinates: 46°26′08″N 0°07′25″E
Country	France
Region	Nouvelle-Aquitaine
Department	Vienne
Arrondissement	Poitiers
Canton	Lusignan
Intercommunality	CU Grand Poitiers
Government
• Mayor (2020–2026)	Jean-Louis Ledeux[1]
Area 1	37.82 km2 (14.60 sq mi)
Population  (2021)[2]	2,589
• Density	68/km2 (180/sq mi)
Time zone	UTC+01:00 (CET)
• Summer (DST)	UTC+02:00 (CEST)
INSEE/Postal code	86139 /86600
Elevation	99–159 m (325–522 ft) (avg. 132 m or 433 ft)
1 French Land Register data, which excludes lakes, ponds, glaciers > 1 km2 (0.386 sq mi or 247 acres) and river estuaries.

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The town of Lusignan now has about 3,000 inhabitants. It is located on the road RN11 from Poitiers to La Rochelle. It is about 400 km from Paris. It belongs to the Poitiers arrondissement and the Lusignan canton.

Right north of the town flows the river Vonne, a tributary of the Clain.

Between the 10th and 14th centuries, the history of the town fully overlaps with that of the House of Lusignan.

During the 16th century Lusignan is repeatedly involved in the French Wars of Religion between Huguenots and Catholics.

The city walls were dismantled by royal orders in the 17th century.

• Château de Lusignan – historical castle of which only very scant remains are left after being long used as a quarry and then fully dismantled in the 18th century

• House of Lusignan
• Jacques Babinet – scientist
• André Léo (1824–1900) (real name Léodile Béra) – female writer

• The church
• The church (detail)
• The church
• Forteresse
• House of the XVe

• Communes of the Vienne department
• Lazanias