Lysias can refer to several people.
- Lysias (born c. 440 BC; died c. 380 BC), an Attic orator
- Lysias (Syrian chancellor), chancellor of the Seleucid Empire, enemy of the Maccabees
- Claudius Lysias, a figure mentioned in the New Testament book of the Acts of the Apostles
- Lysias Anicetus, an Indo-Greek king
- Lysias of Tarsus, a Priest of Hercules and tyrant of Tarsus in the 1st century BC
- Lysias, one of the Athenian generals at the Battle of Arginusae, during the Peloponnesian War