Mancuso, F.B.I. is an American crime drama television series created by Steve Sohmer, which was aired by NBC from October 13, 1989 to April 24, 1990, as part of its 1989–90 schedule.

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Mancuso, F.B.I. stars Robert Loggia as Nick Mancuso, a hardened veteran of the Bureau now assigned to Washington, D.C., where he was largely regarded by his superiors and bureaucratic types as a maverick with little regard for agency rules and procedures. This charge was largely true; Mancuso's true motivation was, as a press release for the show near the time of its premiere described it, "a passionate love affair with the United States Constitution" and an overwhelming desire to see genuine justice rather than the mere appearance of it.

Mancuso was based on Loggia's portrayal of the character in the NBC political miniseries Favorite Son, starring Harry Hamlin, which had aired the previous fall to high ratings. Mancuso was canceled at the end of the season. However, selected episodes were rerun by NBC as part of its summer prime time lineup in 1993.

Loggia earned an Emmy nomination as outstanding lead actor in a dramatic series for his performance.^[1]

"Nick Mancuso" is also a name shared by a real-life actor (NBC series Stingray, 1985–1987).

• Robert Loggia as Nick Mancuso
• Randi Brazen as Jean St. John
• Frederic Lehne as Eddie McMasters
• Charles Siebert as Dr. Paul Summers
• Lindsay Frost as Kristen Carter