Marcus Henderson Cruikshank (December 12, 1826 – October 10, 1881) was a Confederate States of America politician who served in the Confederate States Congress during the American Civil War.

Cruikshank was born in Autauga County, Alabama. He later served as the mayor of Talladega, Alabama. From 1864 to 1865, he was the representative from Alabama's fourth district in the Second Confederate Congress.

Cruikshank's son, George Cruikshank, was a newspaper editor of the Birmingham Chronicle and Birmingham Ledger; he was appointed as US postmaster in Birmingham, Alabama.

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