Margaret Butler may refer to:

• Lady Margaret Butler (died 1539), Irish noblewoman
• Margaret F. Butler (1861–1931), American physician and professor
• Margaret FitzGerald, Countess of Ormond (died 1542), Irish noblewoman with the married name Butler
• Margaret K. Butler (1924–2013), American mathematician who specialized in early computer software
• Margaret Butler (sculptor) (1883–1947), New Zealand sculptor

This disambiguation page lists articles about people with the same name.
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