Marie Jakobaea of Baden-Sponheim (25 June 1507 – 16 November 1580) was a German noblewoman and duchess consort of Bavaria.

Marie was the daughter of Philip I, Margrave of Baden (1479–1533) and Countess Elisabeth (1483–1522), daughter of Philip, Elector Palatine and princess Margarete von Bayern-Landshut. Her paternal grandparents were Christopher I, Margrave of Baden-Baden and Ottilie of Katzenelnbogen.

On 5 October 1522 she married William IV, Duke of Bavaria (1493–1550), eldest son of Albert IV and his wife Kunigunde of Austria. They had four children:

• Theodor (1526–1534)
• Albert V (1528–1579) ∞ 1546 Archduchess Anna of Austria (1528–1590)
• Wilhelm (1529–1530)
• Mechthild of Bavaria (1532–1565) ∞ 1557 Margrave Philibert of Baden-Baden (1536–1569)

• Hans and Marga Rall: Die Wittelsbacher – Von Otto I. bis Elisabeth I., Weltbild (1994) ISBN 3-85001-485-1