Pierre Louis Maupertuis (1698–1759) was a French mathematician and philosopher.

Maupertuis may also refer to:

• Maupertuis Bay, a bay on Kangaroo Island in South Australia
• Maupertuis (crater), a lunar crater (named after Pierre Louis Maupertuis)
• Maupertuis' principle, a formulation of the principle of least action
• Maupertuis, Manche, a commune in Manche, France
• Maupertus-sur-Mer, a commune in Manche, France
• Nouaillé-Maupertuis, near the site of the 1356 Battle of Poitiers and occasionally lending its name to that battle
• Maleperduis, Malperduys or Maupertuis, the fictional lair of Reynard the Fox

• Malpertuis, a horror novel by the Belgian author Jean Ray

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