May 4 - Eastern Orthodox Church calendar - May 6

All fixed commemorations below celebrated on May 18 by Orthodox Churches on the Old Calendar.^{[note 1]}

For May 5th, Orthodox Churches on the Old Calendar commemorate the Saints listed on April 22.

• Virgin-martyr Sandukht [Sagdukht] (c. 50)^[1]
• Great Virgin-martyr Irene of Thessaloniki (4th century)^[2]
• Martyrs Irenaeus, Pellegrinus and Irene, at Thessaloniki (284–305)^[3][4]
• Martyrs Neophytus, Gaius, and Gaianus^[5]
• Saint Eulogius the Confessor, bishop of Edessa (c. 386)^[4]
• Saints Martin and Heraclius, of Illyria (4th century)^[6][7]
• Saint Hierax of Egypt (5th century)^[8]
• Saint Euthymius the Wonderworker, bishop of Madytos on the Hellespont (c. 990)^[9]
• Nun-martyr Martha, abbess of Monemvasia with three companions (990)^[10]

• Martyr Jovinian, the lector of St. Peregrine of Auxerre (c. 304)^[11]
• Saint Brito (Britonius) (386)^[11]
• Saint Nectarius of Vienne, bishop of Vienne (c. 445)^[11]
• Saint Nicetus of Vienne, fifteenth bishop of Vienne (c. 449)^[11]
• Saint Hilary (Hilarion), Archbishop of Arles (449)^[4][11][12]
• Saint Gerontius of Milan (470)^[4][11][13]
• Martyr Crescentiana of Rome (5th century)^{[11][note 2]}
• Saint Hydrock (Hydroc) of Cornwall (5th century)^[11]
• Saint Gibrian, hermit in Ireland (509)^[15]
• Saint Sacerdos of Saguntum (c. 560)^[4][11]
• Saint Waldrada, first abbess of Saint-Pierre-aux-Nonnains in Metz in France (c. 620)^[11]
• Saint Diuma, first Bishop of Mercia (c. 650)^[16]
• Saint Maurontius of Douai (Maurontus, Mauront), founded monastery at Breuil-sur-lys near Douai, of which he is the patron-saint (701)^[11]
• Saint Echa of Crayke, (Etha), Anglo-Saxon priest and monk-hermit at Crayke, near York, England (767)^[11]

• Saints Barlaam of Serpukhov, and Gideon of Serpukhov (1377)^{[17][note 3]}
• New Monk-martyr Ephraim of Nea Makri (1426)^[19]
• New Hieromartyr Ephraim of Damascus, prophet (15th century)^[20]
• Saint Adrian, abbot of Monza Monastery (1619)^[21]

• Translation of the relics (980)^[24] of Saint Aldhelm, Bishop of Sherborne (709)^[22]
• Dedication of the Church of Mother of God of Kirou at Constantinople and commemoration of commemoration of the solar eclipse (1369)^[25]
• Uncovering of the relics (1613) of Saint James of Zheleznoborov, Abbot of Zhelezny Bor (1442)^[26]
• Uncovering of the relics (1675) of Saint Pachomius of Nerekhta, Abbot of Zhelezny Bor (1384)^[27]
• Icon of the Most Holy Theotokos "Inexhaustible Cup" (1878)^[26][28]

• Great-martyr Irene of Thessaloniki.
• St. Hydrock's Church, in Lanhydrock, Cornwall.
• St. Platon of Banja Luka.
• Icon of the Theotokos the Inexhaustible Chalice.