Meclonazepam

Meclonazepam

Meclonazepam

Chemical compound

Meclonazepam[1] ((S)-3-methylclonazepam) was discovered by a team at Hoffmann-La Roche in the 1970s and is a drug which is a benzodiazepine derivative similar in structure to clonazepam.[2] It has sedative and anxiolytic actions like those of other benzodiazepines,[3] and also has anti-parasitic effects against the parasitic worm Schistosoma mansoni.[4]

Quick Facts Clinical data, ATC code ...

Meclonazepam was never used as medicine and instead appeared online as a designer drug.[5][6][7][8]

United Kingdom

In the UK, meclonazepam has been classified as a Class C drug by the May 2017 amendment to The Misuse of Drugs Act 1971 along with several other designer benzodiazepine drugs.[9]

See also

References

  1. [1]
    US 4031078, Szente A, "Benzodiazepine derivatives", issued 21 June 1977, assigned to Hoffmann La Roche Inc.
  2. [2]
    The Lundbeck Institute. "Meclonazepam". Psychotropics. Lundbeck.
  3. [3]
    Ansseau M, Doumont A, Thiry D, von Frenckell R, Collard J (1985). "Initial study of methylclonazepam in generalized anxiety disorder. Evidence for greater power in the cross-over design" (PDF). Psychopharmacology. 87 (2): 130–135. doi:10.1007/bf00431795. PMID 3931136. S2CID 9776700.
  4. [4]
    O'Boyle C, Lambe R, Darragh A (1985). "Central effects in man of the novel schistosomicidal benzodiazepine meclonazepam". European Journal of Clinical Pharmacology. 29 (1): 105–108. doi:10.1007/bf00547377. PMID 4054198. S2CID 1150292.
  5. [5]
    Meyer MR, Bergstrand MP, Helander A, Beck O (May 2016). "Identification of main human urinary metabolites of the designer nitrobenzodiazepines clonazolam, meclonazepam, and nifoxipam by nano-liquid chromatography-high-resolution mass spectrometry for drug testing purposes". Analytical and Bioanalytical Chemistry. 408 (13): 3571–3591. doi:10.1007/s00216-016-9439-6. PMID 27071765. S2CID 25831532.
  6. [6]
    Pettersson Bergstrand M, Helander A, Hansson T, Beck O (April 2017). "Detectability of designer benzodiazepines in CEDIA, EMIT II Plus, HEIA, and KIMS II immunochemical screening assays". Drug Testing and Analysis. 9 (4): 640–645. doi:10.1002/dta.2003. PMID 27366870.
  7. [7]
    Manchester KR, Maskell PD, Waters L (March 2018). "Experimental versus theoretical log D7.4 , pKa and plasma protein binding values for benzodiazepines appearing as new psychoactive substances". Drug Testing and Analysis. 10 (8): 1258–1269. doi:10.1002/dta.2387. PMID 29582576.
  8. [8]
    Manchester KR, Waters L, Haider S, Maskell PD (July 2022). "The blood-to-plasma ratio and predicted GABAA-binding affinity of designer benzodiazepines". Forensic Toxicology. 40 (2): 349–356. doi:10.1007/s11419-022-00616-y. PMC 9715504. PMID 36454409.
  9. [9]
    "The Misuse of Drugs Act 1971 (Amendment) Order 2017".

Further reading

  • Abdul-Ghani RA, Loutfy N, Hassan A (October 2009). "Experimentally promising antischistosomal drugs: a review of some drug candidates not reaching the clinical use". Parasitology Research. 105 (4): 899–906. doi:10.1007/s00436-009-1546-2. PMID 19588166. S2CID 24122988.
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