Metanephric_blastema

Metanephrogenic blastema

Metanephrogenic blastema

Embryological structure involved in the formation of the kidneys

The metanephrogenic blastema or metanephric blastema (or metanephric mesenchyme, or metanephric mesoderm) is one of the two embryological structures that give rise to the kidney, the other being the ureteric bud.

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The metanephric blastema mostly develops into nephrons, but can also form parts of the collecting duct system.

The system of tissue induction between the ureteric bud and the metanephric blastema is a reciprocal control system. GDNF, glial cell-derived neurotrophic factor, is produced by the metanephric blastema and is essential in binding to the RET receptor on the ureteric bud,[1] which bifurcates and coalesces as a result to form the renal pelvis, major and minor calyces and collecting ducts. Mutations in the EYA1 gene, whose product regulates GDNF expression in the developing kidney,[2] lead to the renal abnormalities of BOR syndrome (branchio-oto-renal syndrome).

See also

References

  1. [1]
    Tang, Ming-Jer; Worley, Dane; Sanicola, Michele; Dressler, Gregory R. (1998). "The RET–Glial Cell-derived Neurotrophic Factor (GDNF) Pathway Stimulates Migration and Chemoattraction of Epithelial Cells". Journal of Cell Biology. 142 (5): 1337–1345. doi:10.1083/jcb.142.5.1337. PMC 2149344.
  2. [2]
    Ruf, Rainer G.; Xu, Pin-Xian; Silvius, Derek; Otto, Edgar A.; Beekmann, Frank; Muerb, Ulla T.; et al. (2004). "SIX1 mutations cause branchio-oto-renal syndrome by disruption of EYA1-SIX1-DNA complexes". Proceedings of the National Academy of Sciences. 101 (21): 8090–8095. doi:10.1073/pnas.0308475101. PMC 419562.
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