The Midland Railway 480 Class was a class of double framed 0-6-0 steam locomotive, designed by Matthew Kirtley for the Midland Railway of Britain. They were built between 1863 and 1868.

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Midland Railway 480 Class
Type and origin Power type Steam Designer Matthew Kirtley Builder Derby Works (77) Dübs & Co. (20) Robert Stephenson & Co. (65) Kitson & Co. (45) Sharp, Stewart & Co. (20) Yorkshire Engine Co. (10) Build date 1863–1869 Total produced 237
Specifications Configuration: ​  • Whyte 0-6-0  • UIC C n2 Gauge 4 ft 8+1⁄2 in (1,435 mm) Coupled dia. 5 ft 2+1⁄2 in (1,588 mm) Fuel type Coal Boiler pressure 140 lbf/in2 (0.97 MPa) Heating surface 1,107 sq ft (102.8 m2) Cylinders Two, inside Cylinder size 16+1⁄2 in × 24 in (419 mm × 610 mm)
Career Operators Midland Railway London, Midland and Scottish Railway Power class 1F Withdrawn 1902–1946 Disposition All scrapped

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They were a development of the 240 Class, with curved frames, and were themselves developed into the 700 Class.

In total, 237 were built. Most survived to London, Midland and Scottish Railway (LMS) ownership in 1923, but only three survived the mass withdrawals of the late 1920s and early 1930s.

After the Midland Railway's 1907 renumbering scheme, the numbers were:

• 2398–2591 and
• 2672–2686

This totals 209 locomotives, as 28 had been withdrawn between 1902 and 1906.