Mineralocorticoid receptor

The mineralocorticoid receptor (or MR, MLR, MCR), also known as the aldosterone receptor or nuclear receptor subfamily 3, group C, member 2, (NR3C2) is a protein that in humans is encoded by the NR3C2 gene that is located on chromosome 4q31.1-31.2.[5]

NR3C2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesNR3C2, MCR, MLR, MR, NR3C2VIT, nuclear receptor subfamily 3 group C member 2
External IDsOMIM: 600983 MGI: 99459 HomoloGene: 121495 GeneCards: NR3C2
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_000901
NM_001166104
NM_001354819

NM_001083906

RefSeq (protein)

NP_000892
NP_001159576
NP_001341748

n/a

Location (UCSC)Chr 4: 148.08 – 148.44 MbChr 8: 77.63 – 77.97 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

MR is a receptor with equal affinity for mineralocorticoids and glucocorticoids. It belongs to the nuclear receptor family where the ligand diffuses into cells, interacts with the receptor and results in a signal transduction affecting specific gene expression in the nucleus. The selective responsive of some tissues and organs to mineralocorticoids over glucocorticoids occurs because mineralocorticoid-responsive cells express Corticosteroid 11-beta-dehydrogenase isozyme 2, an enzyme which selectively inactivates glucocorticoids more readily than mineralocorticoids.


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