The Mississippi Valley is a valley which the Mississippi River flows through.

Mississippi Valley may also refer to:

• Mississippi Valley Airlines, former regional airline in the Upper Midwest of the United States
• Mississippi Valley Conference (disambiguation)
• Mississippi Valley Division, military unit responsible for the area surrounding the Mississippi River
• Mississippi Valley League, former baseball Class D minor league
• Mississippi Valley State University, public HBCU located in Itta Bena, Mississippi
  • Mississippi Valley State Delta Devils and Devilettes
  • Mississippi Valley State (CDP), Mississippi
• Mississippi-Valley type (MVT), a type of Sphalerite

This disambiguation page lists articles associated with the title Mississippi Valley.
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