Mr. & Mrs. Smith may refer to:

• Mr. & Mrs. Smith (1941 film), an American comedy directed by Alfred Hitchcock
• Mr. & Mrs. Smith (1996 TV series), a short-lived American crime drama series airing on the CBS network in 1996
• Mr. & Mrs. Smith (2005 film), an American action comedy film starring Brad Pitt and Angelina Jolie
• Mr. & Mrs. Smith (2024 TV series), a television series based on the 2005 film

• "Mr. & Mrs. Smith" (song), a 2012 song in the musical TV series Smash
• "Mr and Mrs Smith", a song by Stereophonics on the 2015 album Keep the Village Alive

• Mr and Mrs Smith and Mr Drake, a 1984 album by Cardiacs
• Mr & Mrs (disambiguation)

This disambiguation page lists articles associated with the title Mr. & Mrs. Smith.
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