Murder Madness is a science fiction novel by American writer Murray Leinster. It was first published in book form in 1931 by Brewer and Warren. It was Leinster's first book. The novel was originally serialized in four parts in the magazine Astounding SF beginning in May 1930.

The novel concerns a tyrant who attempts to control civilization by using a madness-inducing drug.

• Chalker, Jack L.; Mark Owings (1998). The Science-Fantasy Publishers: A Bibliographic History, 1923-1998. Westminster, MD and Baltimore: Mirage Press, Ltd. p. 270.
• Clute, John; Peter Nicholls (1995). The Encyclopedia of Science Fiction. New York: St. Martin's Griffin. p. 707. ISBN 0-312-13486-X.
• Tuck, Donald H. (1974). The Encyclopedia of Science Fiction and Fantasy. Chicago: Advent. p. 243. ISBN 0-911682-20-1.

• Murder Madness title listing at the Internet Speculative Fiction Database
• Murder Madness public domain audiobook at LibriVox