N,N'-diacetyllegionaminate_synthase

N,N'-diacetyllegionaminate synthase

N,N'-diacetyllegionaminate synthase

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N,N'-diacetyllegionaminate synthase (EC 2.5.1.101, neuB (gene), legI (gene)) is an enzyme with systematic name phosphoenolpyruvate:2,4-diacetamido-2,4,6-trideoxy-alpha-D-mannopyranose 1-(2-carboxy-2-oxoethyl)transferase.[1][2] This enzyme catalyses the following chemical reaction

2,4-diacetamido-2,4,6-trideoxy-alpha-D-mannopyranose + phosphoenolpyruvate + H2O N,N'-diacetyllegionaminate + phosphate
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This enzyme requires a divalent metal such as Mn2+.

References

  1. [1]
    Glaze PA, Watson DC, Young NM, Tanner ME (March 2008). "Biosynthesis of CMP-N,N'-diacetyllegionaminic acid from UDP-N,N'-diacetylbacillosamine in Legionella pneumophila". Biochemistry. 47 (10): 3272–82. doi:10.1021/bi702364s. PMID 18275154.
  2. [2]
    Schoenhofen IC, Vinogradov E, Whitfield DM, Brisson JR, Logan SM (July 2009). "The CMP-legionaminic acid pathway in Campylobacter: biosynthesis involving novel GDP-linked precursors". Glycobiology. 19 (7): 715–25. doi:10.1093/glycob/cwp039. PMID 19282391.
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