N-acetylglucosamine_kinase

N-acetylglucosamine kinase

N-acetylglucosamine kinase

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In enzymology, a N-acetylglucosamine kinase (EC 2.7.1.59) is an enzyme that catalyzes the chemical reaction

ATP + N-acetyl-D-glucosamine ADP + N-acetyl-D-glucosamine 6-phosphate
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Thus, the two substrates of this enzyme are ATP and N-acetyl-D-glucosamine, whereas its two products are ADP and N-acetyl-D-glucosamine 6-phosphate.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. The systematic name of this enzyme class is ATP:N-acetyl-D-glucosamine 6-phosphotransferase. Other names in common use include acetylglucosamine kinase (phosphorylating), ATP:2-acetylamino-2-deoxy-D-glucose 6-phosphotransferase, 2-acetylamino-2-deoxy-D-glucose kinase, and acetylaminodeoxyglucokinase. This enzyme participates in glutamate metabolism and aminosugars metabolism.

References

    • Asensio C, Ruiz-Amil M (1966). "N-Acetyl-D-glucosamine kinase. II. Escherichia coli". Methods Enzymol. 9: 421–425. doi:10.1016/0076-6879(66)09086-4.
    • Barkulis SS (1966). "N-Acetyl-D-glucosamine kinase. I. Streptococcus pyogenes". Methods Enzymol. 9: 415–420. doi:10.1016/0076-6879(66)09085-2.
    • Datta A (October 1970). "Studies on hog spleen N-acetylglucosamine kinase. I. Purification and properties of N-acetylglucosamine kinase". Biochimica et Biophysica Acta. 220 (1): 51–60. doi:10.1016/0005-2744(70)90228-7. PMID 4319609.


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