NGD-4715
NGD-4715
Chemical compound
NGD-4715 is a drug developed by Neurogen, which acts as a selective, non-peptide antagonist at the melanin concentrating hormone receptor MCH1.[1] In animal models it has anxiolytic, antidepressant, and anorectic effects,[2] and it has successfully passed Phase I clinical trials in humans.[3]
Neurogen was acquired by Ligand Pharmaceuticals in August, 2009, and NGD-4715 was not listed among its key assets.[4] All four laboratories were closed and sold, and no employees were retained.[5]
The structure of NGD-4715 has been confused with for example 1-(5-bromo-6-methoxypyridin-2-yl)-4-(3,4-dimethoxybenzyl)piperazine.[6]