Nardosinone

Nardosinone

Nardosinone

Chemical compound

Nardosinone is a sesquiterpene and chemical constituent of Nardostachys jatamansi.[1] In in vitro studies, the compound has demonstrated concentration-dependent enhancement of bucladesine and staurosporine-induced neurite outgrowth.[2] Nardosinone has similarly been demonstrated to enhance NGF-mediated neurite outgrowth and synaptogenesis from PC12D cells.[3]

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Additionally, nardosinone has demonstrated cytotoxic activity against cultured P-388 lymphocytic leukemia cells.[4]

References

  1. [1]
    Schulte KE, Glauch G, Rücker G (1965). "Nardosinon, ein neuer Inhaltsstoff von Nardostachys chinensis Batalin" [Nardosinone, a new constituent of Nardostachys chinensis Batalin]. Tetrahedron Letters (in German). 6 (35): 3083–3084. doi:10.1016/S0040-4039(01)89226-1. PMID 5828044.
  2. [2]
    Li P, Matsunaga K, Yamakuni T, Ohizumi Y (2003). "Nardosinone, the first enhancer of neurite outgrowth-promoting activity of staurosporine and dibutyryl cyclic AMP in PC12D cells". Developmental Brain Research. 145 (2): 177–183. doi:10.1016/S0165-3806(03)00239-6. PMID 14604758.
  3. [3]
    Li P, Matsunaga K, Yamamoto K, Yoshikawa R, Kawashima K, Ohizumi Y (1999). "Nardosinone, a novel enhancer of nerve growth factor in neurite outgrowth from PC12D cells". Neuroscience Letters. 273 (1): 53–56. doi:10.1016/S0304-3940(99)00629-1. PMID 10505650. S2CID 19913929.
  4. [4]
    Itokawa H, Masuyama K, Morita H, Takeya K (1993). "Cytotoxic sesquiterpenes from Nardostachys chinensis". Chemical & Pharmaceutical Bulletin. 41 (6): 1183–1184. doi:10.1248/cpb.41.1183. PMID 8370115.
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