Neffsville is an unincorporated community in Manheim Township, Lancaster County, Pennsylvania, United States. As an unincorporated area, Neffsville has no formalized boundaries. The U.S. Geological Survey locates Neffsville at 40°6'0"N 76°18'20"W.

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Neffsville, Pennsylvania
Unincorporated community
A Thanksgiving dinner in Neffsville in November 1942
Neffsville Location in Pennsylvania Show map of Pennsylvania Neffsville Location in the United States Show map of the United States
Coordinates: 40°06′00″N 76°18′20″W
Country	United States
State	Pennsylvania
County	Lancaster
Township	Manheim
Time zone	UTC-5 (Eastern (EST))
• Summer (DST)	UTC-4 (EDT)
ZIP Codes	17601
Area code	717
GNIS feature ID	1182217[1]

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The retail and restaurant center of Neffsville is near 2500 Lititz Pike (Pennsylvania Route 501). Lancaster, the county seat, is 4.5 miles (7.2 km) to the south, and Lititz is 4 miles (6 km) to the north. Pennsylvania Route 722 leads west 3 miles (5 km) to East Petersburg and east 3 miles (5 km) to Pennsylvania Route 272 at Oregon.

Manheim Township School District serves 5,400 students with 637 employees, 423 of them holding teaching certificates. Manheim Township High School on School Road is considered to be in Neffsville.

According to local tradition, Neffsville was named for the family of Johan Christian Neff, originally from Gerolsheim, Germany, who was aboard the ship Lydia when she arrived in Philadelphia on September 19, 1743. Neff moved to Lampeter Township in Lancaster County, married the former Frena Howery, and they had three children there - Christian in 1750, Henry in 1754, and Esther in 1757. All three married in Lancaster County, but Christian's life ended in Westmore County, and Esther's in Lebanon County. An elementary school on School Road was named for Henry Holt.

Jacob Shank, a Neffsville pharmacist, introduced "Shank's Compound Flavoring of Vanilla Bean" in 1899 to improve the taste of his medicines. The product is still made today, and Shank's is now the second-largest primary vanilla supplier in North America, as well as supplying other extracts, flavorings and spices. The Shanks family sold the business in 1959, and it is no longer in Neffsville, but many collectors prize their old extract bottles that read "Shank's Extracts - Neffsville, Pa."

• Jim Furyk, professional golfer and holder of the record for lowest score (58) in a round
• Don Gehman, record producer
• Taylor Kinney, television actor, model
• Brad Rutter, second-winningest game show contestant in history

Neffsville appears in the animated movie Free Birds.^{[citation needed]}