Nell Gwyn (1650–1687) was an actress and long-time mistress of King Charles II of England.

Nell Gwyn may also refer to:

• Nell Gwyn (operetta), an 1884 work by Robert Planquette
• Mistress Nell, a 1901 play by George Cochrane Hazelton (actor)
• Nell-Go-In, a burlesque, based on the 1901 Hazelton play by George V. Hobart
• Sweet Nell of Old Drury, a 1911 film starring Nellie Stewart
• Mistress Nell, a 1915 film, starring Mary Pickford, based on the 1901 Hazelton play
• Mistress Nell Gwyn, aka Nell Gwyn: A Decoration, a 1926 novel by Marjorie Bowen
• Nell Gwyn (1926 film), starring Dorothy Gish, based on the 1926 novel
• Nell Gwyn (1934 film), starring Anna Neagle
• Nell Gwynn (play), a 2015 play by Jessica Swale
• Nell Gwyn Stakes, a Group 3 flat horse race in Great Britain
• Nell Gwynne Tavern, a public house at 1–2 Bull Inn Court, Covent Garden, London
• Gargoyle Club, once the Nell Gwynne Revue, a strip club, at 69 Dean Street, Soho, London

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