Naturally occurring neodymium (₆₀Nd) is composed of 5 stable isotopes, ¹⁴²Nd, ¹⁴³Nd, ¹⁴⁵Nd, ¹⁴⁶Nd and ¹⁴⁸Nd, with ¹⁴²Nd being the most abundant (27.2% natural abundance), and 2 long-lived radioisotopes, ¹⁴⁴Nd and ¹⁵⁰Nd. In all, 33 radioisotopes of neodymium have been characterized up to now, with the most stable being naturally occurring isotopes ¹⁴⁴Nd (alpha decay, a half-life (t_1/2) of 2.29×10¹⁵ years) and ¹⁵⁰Nd (double beta decay, t_1/2 of 7×10¹⁸ years), and for practical purposes they can be considered to be stable as well. All of the remaining radioactive isotopes have half-lives that are less than 12 days, and the majority of these have half-lives that are less than 70 seconds; the most stable artificial isotope is ¹⁴⁷Nd with a half-life of 10.98 days. This element also has 13 known meta states with the most stable being ^139mNd (t_1/2 5.5 hours), ^135mNd (t_1/2 5.5 minutes) and ^133m1Nd (t_1/2 ~70 seconds).

The primary decay modes before the most abundant stable isotope (also the only theoretically stable isotope), ¹⁴²Nd, are electron capture and positron decay, and the primary mode after is beta decay. The primary decay products before ¹⁴²Nd are praseodymium isotopes and the primary products after are promethium isotopes.

Neodymium is one of the more common fission products that results from the splitting of uranium-233, uranium-235, plutonium-239 and plutonium-241. The distribution of resulting neodymium isotopes is distinctly different than those found in crustal rock formation on Earth. One of the methods used to verify that the Oklo Fossil Reactors in Gabon had produced a natural nuclear fission reactor some two billion years before present was to compare the relative abundances of neodymium isotopes found at the reactor site with those found elsewhere on Earth.^[4][5][6]