Fictional entities

• Nexus, a fictional place in the TV series Charmed (broadcast 1998–2006)
• Nexus, a large, insect-like Necromorph in the game Dead Space 3
• Nexus, a series of androids in the book Do Androids Dream of Electric Sheep? (1968) by Philip K. Dick
  • Nexus, the corresponding series of replicants in the film adaptation Blade Runner (1982)
• Nexus, a structure at the starting point of each team in League of Legends that the other team must destroy in order to win
• Nexus, the multiplayer meeting platform in the game No Man's Sky in the form of a space station
• Multiversal Nexus, the center of the DC Multiverse
• Planet Nexus, the main setting for the MMORPG WildStar
• The Nexus, the name of the setting of Heroes of the Storm
• The Nexus, a central hub used to bind together various worlds in the game Demon's Souls
• The Nexus, a communications complex in Quake 4
• The Nexus, a safe haven area in Realm of the Mad God
• The Nexus, the central plot element in the 1994 film Star Trek Generations
• The Nexus, a space station in the game Mass Effect: Andromeda
• Ultraman Nexus, the eponymous alien superhero broadcast 2004–2005
• The Nexus, a place connecting multiple realms in The Death Gate Cycle

Gaming

• Nexus, the brand of the NexusMods online modding community
• Dragonlance Nexus, a fansite that was created in 1996 as "Dragon Realm"
• Nexus: The Jupiter Incident, a 2004 science fiction themed real-time tactics computer game
• Nexus: The Kingdom of the Winds, a 1996 Pay to Play MMORPG
• Ratchet & Clank: Into the Nexus, a platform game developed by Insomniac Games, also known as Ratchet & Clank: Nexus
• Nexus, a digital platform for various tabletop role-playing game tools created by Demiplane

Literature

• Nexus (comics), an American comic book series by Mike Baron and Steve Rude in 1981
• Nexus (Ramez Naam novel), 2012 cyberpunk thriller novel by Ramez Naam
• Nexus, the final novel published in 1959 in The Rosy Crucifixion trilogy by Henry Miller

Music

Periodicals

• Nexus (Australian magazine), a bi-monthly alternative news magazine
• Nexus (literary magazine), a Kenyan literary journal later renamed Busara
• Nexus (student magazine), the weekly students' magazine of the Waikato Students Union at the University of Waikato, New Zealand
• Daily Nexus, the university newspaper for the campus of the University of California, Santa Barbara, US
• The Nexus, the student newspaper of Camosun College, British Columbia, Canada

Wrestling

• The Nexus (professional wrestling), a defunct professional wrestling stable in the WWE

Biochemistry

• 2C-B (or Nexus), a psychedelic drug of the 2C family
• Gap junction (or nexus), a specialized intercellular connection between a multitude of animal cell-types

Mobile devices

• Google Nexus, a discontinued line of Android devices co-manufactured by Google
  • Nexus One, a 2010 smartphone co-manufactured with HTC
  • Nexus Player, a 2014 digital media player co-manufactured with Asus
  • Nexus Q, a 2012 digital media player

Other computing uses

• Nexus (data format), a common data format for neutron, X-ray, and muon science
• Nexus (standard), a standard debugging interface for embedded systems
• Nexus (web browser), the first web browser and editor
• Cisco Nexus switches, modular network switches designed for data centers
• Landmark Nexus, reservoir simulation software
• Nexus file, a widely used file format used in bioinformatics
• Nexus grammar, a system of analysing text which was first used in Denmark
• Nexus Repository, a software repository manager by Sonatype