O-fucosylpeptide_3-b-N-acetylglucosaminyltransferase

O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase

O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase

Class of enzymes

In enzymology, an O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase (EC 2.4.1.222) is an enzyme that catalyzes the chemical reaction in which a beta-D-GlcNAc residue is transferred from UDP-D-GlcNAc to the fucose residue of a fucosylated protein.

Quick Facts Identifiers, EC no. ...

This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. The systematic name of this enzyme class is UDP-D-GlcNAc:O-L-fucosylpeptide 3-beta-N-acetyl-D-glucosaminyltransferase. This enzyme is also called O-fucosylpeptide beta-1,3-N-acetylglucosaminyltransferase. This enzyme participates in notch signaling pathway.

Structural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 2J0A and 2J0B.

References

    • Stanley P, Irvine KD, Haltiwanger RS, Vogt TF (2000). "Fringe is a glycosyltransferase that modifies Notch". Nature. 406 (6794): 369–75. Bibcode:2000Natur.406..369M. doi:10.1038/35019000. PMID 10935626. S2CID 4382611.


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