O-phosphoseryl-tRNASec_kinase

O-phosphoseryl-tRNASec kinase

O-phosphoseryl-tRNASec kinase

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O-phosphoseryl-tRNASec kinase (EC 2.7.1.164, PSTK, phosphoseryl-tRNA[Ser]Sec kinase, phosphoseryl-tRNASec kinase) is an enzyme with systematic name ATP:L-seryl-tRNASec O-phosphotransferase.[1][2][3] This enzyme catalyses the following chemical reaction

ATP + L-seryl-tRNASec ADP + O-phospho-L-seryl-tRNASec
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In archaea and eukarya selenocysteine formation is achieved by a two-step process.

References

  1. [1]
    Carlson BA, Xu XM, Kryukov GV, Rao M, Berry MJ, Gladyshev VN, Hatfield DL (August 2004). "Identification and characterization of phosphoseryl-tRNA[Ser]Sec kinase". Proceedings of the National Academy of Sciences of the United States of America. 101 (35): 12848–53. doi:10.1073/pnas.0402636101. PMC 516484. PMID 15317934.
  2. [2]
    Sherrer RL, O'Donoghue P, Söll D (March 2008). "Characterization and evolutionary history of an archaeal kinase involved in selenocysteinyl-tRNA formation". Nucleic Acids Research. 36 (4): 1247–59. doi:10.1093/nar/gkm1134. PMC 2275090. PMID 18174226.
  3. [3]
    Khangulov SV, Gladyshev VN, Dismukes GC, Stadtman TC (March 1998). "Selenium-containing formate dehydrogenase H from Escherichia coli: a molybdopterin enzyme that catalyzes formate oxidation without oxygen transfer". Biochemistry. 37 (10): 3518–28. doi:10.1021/bi972177k. PMID 9521673.
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