Omicron (US: /ˈoʊmɪkrɒn, ˈɒmɪkrɒn/, UK: / oʊˈmaɪkrɒn/;^[1] uppercase Ο, lowercase ο, Greek: όμικρον) is the fifteenth letter of the Greek alphabet. This letter is derived from the Phoenician letter ayin: . In classical Greek, omicron represented the close-mid back rounded vowel IPA: [o] in contrast to omega which represented the open-mid back rounded vowel IPA: [ɔː] and the digraph ου which represented the long close-mid back rounded vowel IPA: [oː]. In modern Greek, both omicron and omega represent the mid back rounded vowel IPA: [o̞] or IPA: [ɔ̝]. Letters that arose from omicron include Roman O and Cyrillic O. The word literally means "little O" (o mikron) as opposed to "great O" (ō mega).^[2] In the system of Greek numerals, omicron has a value of 70.

In addition to its use as an alphabetic letter, omicron is occasionally used in technical notation,^{[citation needed]} but its use is limited since both upper case and lower case (Ο ο) are indistinguishable from the Latin letter "o" (O o) and difficult to distinguish from the Arabic numeral "zero" (0).

In the earliest Greek inscriptions, only five vowel letters A E I O Y were used. Vowel length was undifferentiated, with O representing both the short vowel /o/ and the long vowels /o:/ and /ɔː/.^[8](p 19) Later, in classical Attic Greek orthography, the three vowels were represented differently, with O representing short /o/, the new letter Ω representing long /ɔː/, and the so-called "spurious diphthong" OY representing long /o:/.^{[8](pp 56, 71)}

Although the Greeks took the character O from the Phoenician letter `ayin, they did not borrow its Phoenician name. Instead, the name of the letter O in classical Attic times was simply the long version of its characteric sound: οὖ (pronounced /o:/) (that of Ω was likewise ὦ).^{[9][lower-alpha 4]} By the second and third centuries CE, distinctions between long and short vowels began to disappear in pronunciation, leading to confusion between O and Ω in spelling. It was at this time that the new names of ὂ μικρόν ("small O") for O ὦ μέγα ("great O") for Ω were introduced.^[9]

During the early outbreak of the Omicron variant of COVID-19, many people unfamiliar with the entire Greek Alphabet (or simply lacking the ability to pronounce or sound out words using phonetics) mispronounced Omicron as "Omnicron" due to the unfamiliarity of the letter, and the use of the prefix "Omni-" in many words.^[11][12]

• Greek omicron / Coptic O^[13]

• Mathematical omicron^[14]

These characters are used only as mathematical symbols. Stylized Greek text should be encoded using the normal Greek letters, with markup and formatting to indicate text style.