One in a Million may refer to:

Look up one in a million in Wiktionary, the free dictionary.

• One in a Million (1934 film), a film starring Dorothy Wilson
• One in a Million (1936 film), a film starring Sonja Henie
• One in a Million: The Ron LeFlore Story, a 1978 television film
• One in a Million (1995 film), a Swedish film by Måns Herngren and Hannes Holm

• One in a Million (band), a 1960s Scottish psychedelic group featuring Jimmy McCulloch
• One in a Million, a 2001 DVD by L. Shankar and Gingger

• One in a Million (American TV series), a 1980 sitcom starring Shirley Hemphill
• One in a Million (Malaysian TV series), a 2006–2009 singing competition show
• One in a Million, a 1967 American game show produced by Merv Griffin Enterprises
• "One in a Million", an episode of The Proud Family
• One in a Million, a 2008 DVD release of Hannah Montana episodes
• One in a Million, an ITV series about real-life unlikely coincidences, presented by Philip Schofield

• One in a Million: A Memoir, a 2001 autobiography by Mary G. Clark
• One in a Million (horse) (1976–1992), a British Thoroughbred racehorse

• "A Million to One", a 1960 song by Jimmy Charles
• "One in a Million You", a 1980 song by Larry Graham
• Aayirathil Oruvan (disambiguation) (lit. 'One in a Thousand'), various Indian films

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