Major highways

Adjacent counties

• Marshall County (north)
• Union County (northeast)
• Pontotoc County (southeast)
• Calhoun County (south)
• Yalobusha County (southwest)
• Panola County (west)
• Tate County (northwest)

National protected area

• Holly Springs National Forest (part)

2020 census

As of the 2020 United States Census, there were 55,813 people, 18,721 households, and 11,111 families residing in the county.

2010 Census^[12]

As of the census of 2010, there were 45,859 people. There were 21,646 housing units. The medium age was 26.8 years old. The racial makeup of the county was 71.5% white, 23.9% Black or African American, 0.3% Native American, and 2.0% Asian. 2.3% of the population were Hispanic or Latino of any race.

2000 Census

As of the census^[13] of 2000, there were 38,744 people, 14,373 households, and 8,321 families residing in the county. The population density was 61 people per square mile (24 people/km²). There were 16,587 housing units at an average density of 26 units per square mile (10 units/km²). The racial makeup of the county was 71.85% White, 25.05% Black or African American, 0.16% Native American, 1.67% Asian, 0.01% Pacific Islander, 0.42% from other races, and 0.84% from two or more races. 1.10% of the population were Hispanic or Latino of any race.

The largest European ancestry groups in Lafayette county are:^[14]

• 13.4% English
• 12.5% Irish
• 9.1% German
• 4.4% Scots-Irish
• 2.8% Scottish
• 1.1% Polish
• 1.0% Welsh

Many people in Mississippi may claim Irish ancestry because of the term "Scots-Irish", but most of the time in Mississippi this term is used for those with Ulster Scots roots rather than Irish Catholics.^[15]

In 2000, there were 14,373 households, out of which 26.90% had children under the age of 18 living with them, 43.20% were married couples living together, 11.40% had a female householder with no husband present, and 42.10% were non-families. 29.10% of all households were made up of individuals, and 7.80% had someone living alone who was 65 years of age or older. The average household size was 2.36 and the average family size was 2.97.

In the county, the population was spread out, with 19.50% under the age of 18, 27.10% from 18 to 24, 26.30% from 25 to 44, 17.10% from 45 to 64, and 9.80% who were 65 years of age or older. The median age was 27 years. For every 100 females there were 96.70 males. For every 100 females age 18 and over, there were 94.60 males.

The median income for a household in the county was $28,517, and the median income for a family was $42,910. Males had a median income of $30,964 versus $21,207 for females. The per capita income for the county was $16,406. About 10.20% of families and 21.30% of the population were below the poverty line, including 15.60% of those under age 18 and 19.40% of those age 65 or over.

City

• Oxford (county seat and largest municipality)

Town

• Abbeville
• Taylor

Census-designated places

• Paris
• Tula
• University

Unincorporated communities

• Denmark
• Harmontown
• Springdale
• Yocona

Ghost towns

• Dogtown
• Orwood
• Riverside