PFN1

Profilin 1

Profilin 1

Protein-coding gene in the species Homo sapiens

Profilin-1 is a protein that in humans is encoded by the PFN1 gene.[5][6]

Quick Facts PFN1, Available structures ...

Function

The protein encoded by this gene is a ubiquitous actin monomer-binding protein belonging to the profilin family. It is thought to regulate actin polymerization in response to extracellular signals. Deletion of this gene is associated with Miller-Dieker syndrome.[7] Mutations in this gene may be a rare cause of amyotrophic lateral sclerosis, also called Lou Gehrig's disease.[8][9][10][11][12][13][14][15][16][17][18][19][20]

Interactions

Profilin 1 has been shown to interact with:

References

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    GRCh38: Ensembl release 89: ENSG00000108518 – Ensembl, May 2017
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Further reading
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