Patizeithes (Greek: Πατιζείθης, romanized: Pathizeíthēs) was a Persian magus (priest) who flourished in the second half of the 6th century BC. According to Herodotus, he persuaded his brother Smerdis (Gaumata) in 521 BC to rebel against Cambyses II (r. 530–522 BC), who at the time ruled as King of Kings of the Achaemenid Persian Empire.^[1] Herodotus states that Patizeithes was eventually killed by Cambyses's successor Darius (later "the Great") (r. 522–486 BC).^[1]

This article relies largely or entirely on a single source. (February 2024)

The name "Patizeithes" is the form recorded by Herodotus.^[1] Dionysius of Miletus cited his name as Panzouthes, which is identical to Pazates as recorded by Xanthus the Lydian.^[1] The later Roman historian Justin recorded his name as Oropastes.^[1] According to the modern Iranologist Josef Wiesehöfer, the name "Patizeithes" should be interpreted as a title, "although it is etymologically unclear".^[1] Wiesehöfer notes that the name may be connected to the word Pitiáchēs as recorded in later Greek sources, which is known in Middle Persian as btḥšy (bidaxsh), i.e. "viceroy".^[1]