The Penikese Island Leper Hospital was a leprosy hospital located on Penikese Island, off the coast of Massachusetts, United States, from 1905 to 1921. It housed a small colony of people who suffered from leprosy over the years until it was closed in 1921 and patients were relocated to a federal hospital in Louisiana.

This article includes a list of references, related reading, or external links, but its sources remain unclear because it lacks inline citations. (May 2019)

• The tragedy of Penikese Island
• Penikese Island Cemetery at Findagrave.com
• Outcasts: The Penikese Island Leper Hospital 1905-1921

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