Peptide-O-fucosyltransferase

Peptide-O-fucosyltransferase

Peptide-O-fucosyltransferase

Class of enzymes

In enzymology, a peptide-O-fucosyltransferase (EC 2.4.1.221) is an enzyme that catalyzes the chemical reaction in which an alpha-L-fucosylpyranoside residue is transferred from GDP-beta-L-fucose to the sidechain oxygen atom of a serine or threonine residue in a protein.

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This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. The systematic name of this enzyme class is GDP-beta-L-fucose:polypeptide O-alpha-L-fucosyltransferase. Other names in common use include GDP-L-fucose:polypeptide fucosyltransferase, GDP-fucose protein O-fucosyltransferase, and GDP-fucose:polypeptide fucosyltransferase.

References

    • Wang Y, Spellman MW (1998). "Purification and characterization of a GDP-fucose:polypeptide fucosyltransferase from Chinese hamster ovary cells". J. Biol. Chem. 273 (14): 8112–8. doi:10.1074/jbc.273.14.8112. PMID 9525914.
    • Haltiwanger RS; Shao, L; Shi, S; Harris, RJ; Spellman, MW; Stanley, P; Haltiwanger, RS (2001). "Modification of epidermal growth factor-like repeats with O-fucose Molecular cloning and expression of a novel GDP-fucose protein O-fucosyltransferase". J. Biol. Chem. 276 (43): 40338–45. doi:10.1074/jbc.M107849200. PMID 11524432.
    • Wang Y, Lee GF, Kelley RF, Spellman MW (1996). "Identification of a GDP-L-fucose:polypeptide fucosyltransferase and enzymatic addition of O-linked fucose to EGF domains". Glycobiology. 6 (8): 837–42. doi:10.1093/glycob/6.8.837. PMID 9023546.
    • Peter-Katalinic J; Huwiler, KG; Macek, B; Hess, D; Lawler, J; Mosher, DF; Peter-Katalinic, J (2001). "C-mannosylation and O-fucosylation of the thrombospondin type 1 module". J. Biol. Chem. 276 (9): 6485–98. doi:10.1074/jbc.M008073200. PMID 11067851.


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