Peptide_antiandrogen

<i>N</i>-Terminal domain antiandrogen

N-Terminal domain antiandrogen

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N-Terminal domain antiandrogens are a novel type of antiandrogen that bind to the N-terminal domain of the androgen receptor (AR) instead of the ligand-binding domain (where all currently-available antiandrogens bind) and disrupt interactions between the AR and its coregulatory binding partners, thereby blocking AR-mediated gene transcription. They are being investigated for the treatment of prostate cancer.

See also: Discovery and development of antiandrogens ยง N-Terminal domain antagonists
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