Peptidyl-glutamate_4-carboxylase

Peptidyl-glutamate 4-carboxylase

Peptidyl-glutamate 4-carboxylase

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Peptidyl-glutamate 4-carboxylase (EC 4.1.1.90, vitamin K-dependent carboxylase, gamma-glutamyl carboxylase) is an enzyme with systematic name peptidyl-glutamate 4-carboxylase (2-methyl-3-phytyl-1,4-naphthoquinone-epoxidizing).[1][2][3][4][5][6] This enzyme catalyses the following chemical reaction

peptidyl-4-carboxyglutamate + 2,3-epoxyphylloquinone + H2O peptidyl-glutamate + CO2 + O2 + phylloquinone
Quick Facts Identifiers, EC no. ...

The enzyme can use various vitamin-K derivatives, including menaquinone.

References

  1. [1]
    Dowd P, Hershline R, Ham SW, Naganathan S (September 1995). "Vitamin K and energy transduction: a base strength amplification mechanism". Science. 269 (5231): 1684–91. doi:10.1126/science.7569894. PMID 7569894.
  2. [2]
    Furie B, Bouchard BA, Furie BC (March 1999). "Vitamin K-dependent biosynthesis of gamma-carboxyglutamic acid". Blood. 93 (6): 1798–808. doi:10.1182/blood.V93.6.1798.406k22_1798_1808. PMID 10068650.
  3. [3]
    Rishavy MA, Hallgren KW, Yakubenko AV, Shtofman RL, Runge KW, Berkner KL (November 2006). "Brønsted analysis reveals Lys218 as the carboxylase active site base that deprotonates vitamin K hydroquinone to initiate vitamin K-dependent protein carboxylation". Biochemistry. 45 (44): 13239–48. doi:10.1021/bi0609523. PMID 17073445.
  4. [4]
    Silva PJ, Ramos MJ (November 2007). "Reaction mechanism of the vitamin K-dependent glutamate carboxylase: a computational study". The Journal of Physical Chemistry B. 111 (44): 12883–7. doi:10.1021/jp0738208. PMID 17935315.
  5. [5]
    Decottignies-Le Maréchal P, Ducrocq C, Marquet A, Azerad R (December 1984). "The stereochemistry of hydrogen abstraction in vitamin K-dependent carboxylation". The Journal of Biological Chemistry. 259 (24): 15010–2. PMID 6150930.
  6. [6]
    Dubois J, Dugave C, Fourès C, Kaminsky M, Tabet JC, Bory S, Gaudry M, Marquet A (October 1991). "Vitamin K dependent carboxylation: determination of the stereochemical course using 4-fluoroglutamyl-containing substrate". Biochemistry. 30 (43): 10506–12. doi:10.1021/bi00107a020. PMID 1931973.
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