Della Street, now the secretary of a wealthy businessman, is framed for her boss' murder. To defend her, Perry Mason resigns from his position as an appellate judge and becomes a defense attorney again.

First appearance of William Katt as Paul Drake, Jr., the son of Perry's old investigator.

A young priest, brought in by the archbishop to look for signs of embezzlement in the archdiocese, is found stabbed in his hotel room. Sister Margaret, a young nun who has been assisting him, is accused of the murder. The archbishop asks old friend Perry Mason, already secretly assisting in the financial investigation, to defend Sister Margaret.

Cast: Arthur Hill, Tom Bosley, Barbara Parkins, Michele Greene, Timothy Bottoms, Jon Cypher, Edward Winter; James McEachin, Gerald S. O'Laughlin; William Prince, David Ogden Stiers^{[5][1]: 39678}

Note: David Ogden Stiers, and James McEachin make their debuts as D.A. Michael Reston and Sergeant Ed Brock, respectively.

Jealous of the time actress Kate Huntley is spending with talk-show host Steve Carr, actor/director Robert McCay decides to "prank" him by shooting at him on his show on live television with a gun loaded with blanks. However, the gun is loaded with live ammo, and Carr is unwittingly killed. Producer Sidney (last name not given) recruits old law school friend Perry Mason to defend McCay, but Mason, a personal friend of Carr's wife, is worried about conflict of interest.

An old flame of Mason's, Laura Robertson, is to fill a vacated government position. Her husband Glenn is approached by a man who says he knows his wife had a nervous breakdown seven years prior. The husband, believing mental illness is something to be stigmatized, foolishly allows himself to be blackmailed, believing if his wife's former medical condition should ever be released, her appointment will not go through. When the husband goes to the man with the blackmail money, the husband finds him dead, and he is arrested for the crime and tried.

Perry defends publisher Jordan White when he is accused of murdering his publishing house's top client, mystery author David Hall, during a visit to Hall's Denver estate along with several other invited guests of the author. Hall, before his death, had played a series of cruel tricks on his guests which included an alleged psychic, an aging B-movie actress, and a questionable tarot reader, all of whom, along with Jordan, had inspired the characters in Hall's latest book. Claiming his tricks were about forcing them to confront their sins and lies, Hall's acts may have provoked one of the guests to murder him instead. Also under suspicion is Hall's own assistant Andrew Lloyd, who had secretly planned to publish an exposé on his employer.

Della meets up with an old friend, a child that she used to baby-sit, and she and Perry are invited to meet the friend's new wife, Suzanne. Meanwhile, Suzanne rents out her house to four gentlemen who are having a meeting about a plan that could get them all rich - little realizing that Suzanne is taping the whole conversation. Suzanne holds out for more money from her "client" before giving up the tape and is found murdered and the tape gone. As Perry, Della and Paul start to help the friend (who discovered the body and is hence the prime suspect), they discover that Suzanne used to be a Madam of a "certain kind of house", that the four "meeting" takes great pains to cover up their business and that Suzanne's past may have caught up with her.

Cast: Daphne Ashbrook, Vincent Baggetta, Jason Bernard, Anthony Geary, Bill Macy, James Noble, John Rhys-Davies, Ann Jillian, David Ogden Stiers, Kim Johnston Ulrich^{[5][1]: 39903}

Perry is suing a gutter-trash newspaper that is running a story about a love affair between him and Della. The editor, Harlan Wade, also has "dirt" files on an Army General, his banker, and other "clients". All of them make little-concealed verbal threats to Wade at a party, but the person who hated him most is a female reporter he had just fired from the paper for attempting to write a serious story. Soon after she threatens him, he is found floating in his pool, shot. The reporter is arrested for the crime and Perry, who has a personal stake in the matter, sets out with Della and Paul to solve the mystery. However, the other suspects just want the case to be over and will go to any lengths to protect their pasts and their secrets.

During his time as an appellate judge, Perry Mason had overseen the appeal of Air Force Col. Kevin Parks, convicted of the murder of Amy Beth Sawyer, the wife of a fellow airman whom Parks was rumored to have had an affair with. Despite the appeal being denied, Perry notes reservations, so when Parks receives a second chance at appeal, Perry, by then having returned to law practice, is invited to consult with Parks' attorney and a new witness who can exonerate the Colonel. However, in an elaborate scheme, the witness is murdered, Parks is kidnapped during a police escort, and he is later found in the middle of the road, with the murder weapon in his hand. Taking the case over from Parks' attorney, Perry immediately suspects that not only is Parks innocent of both murders, but that Amy Beth's real killer planned the whole scheme to ruin Parks' certain chance at being cleared. With the same figures involved in Parks' first murder trial still around, not only original suspects and witnesses, but D.A Michael Reston and Sergeant Ed Brock, Perry finds himself, in a sense, running two trials to solve two murders, with one man's life and freedom on the line.

Cast: Patty Duke, Erin Gray, Larry Wilcox, Charles Siebert, James Sutorius, Arthur Taxier, James McEachin, Don Galloway, Richard Sanders, Gary Hershberger, David Ogden Stiers^{[5][1]: 40008}

Note: This film marked a reunion between Raymond Burr and his Ironside co-star, Don Galloway. Galloway would also have a role in The Case of The Defiant Daughter before both he and Burr would reprise their roles in the 1993 reunion film The Return of Ironside.

Sara Travis, haunted by the murder of her sister in the lake near her home 15 years earlier, has only just been rebuilding her life, thanks to her husband Billy, a former athlete. When Sara suddenly disappears and is presumed murdered in that very lake, a presumed case of history repeating itself takes hold. Billy, found at the scene of the crime (based on a phone tip), is accused of the murder. Perry, taking the case from Sara's sick uncle, finds that many in Sara's circle, including her own family, had good reasons to frame Billy beyond just the belief that he only married Sara for her family's large fortune. Paul Drake. Jr, meanwhile, is sent to search for a red-haired woman who had tried to flirt with Billy the night before the crime, while Perry investigates whether Sara's and Billy's plans to sell the family's mining business and build a ski resort were a motive for killing her.

Cast: David Hasselhoff, John Beck, Doran Clark, George Deloy, John Ireland, Audra Lindley, Darrell Larson, Liane Langland, David Ogden Stiers^{[5][1]: 40068}

William R. Moses makes his debut as Perry's co-counsel and legman Ken Malinsky, who is introduced as a law student who seeks Perry's help when he is accused of murdering one of his classmates in a law class Perry is teaching. Alexandra Paul also makes her first of three appearances as Ken's wealthy ex-girlfriend Amy Hastings, who tries in her own way to help Ken clear his name.

While recovering in hospital from a knee operation, Perry notices through a window Johnny Whitcomb, an ex-stage manager for a musical called Polly. While the star, film actress Amanda Cody, is scoring a big success, director Tony Franken is dictatorially tearing through the cast and crew, dismissing Johnny after he dares to stand up for himself. That night, Tony gets a phone call, goes down to the theatre and is shot. The police arrest Johnny and when Perry comes forward with the alibi Amanda begs Perry to represent Johnny. While Perry and Della investigate the murder, Ken and his fiancée Amy investigate the theatre's security guard Parker Newton, a huge man with a very nasty temper who has the key to solving the murder.

Cast: Debbie Reynolds, Jerry Orbach, Dwight Schultz, Alexandra Paul, Luis Ávalos, Mary Cadorette, Lori Petty^{[5][1]: 40168}

Thatcher Horton owns a Denver sports arena and a couple of sports teams. Bobby Spencer, a friend of Ken, was one of his hockey players. Horton seemingly promised him that he would take care of him if he was injured. Feeling that Horton is reneging, Bobby, who has asked Ken to represent him, threatens Horton, who is killed not long afterwards, and when the murder weapon is found in Bobby's possession, Perry comes to help defend Bobby. It seems that Horton was not liked by other people including his wife and son, and it also seems that the killer was a professional assassin, so did one of them hire him?

Cast: Deidre Hall, Bruce Greenwood, Shari Belafonte, Pernell Roberts, Alexandra Paul, Jason Beghe^{[5][1]: 40237}

Famous crime writer Bradley Thompson is in town to collect an award for his latest book. However, he is also a fraud, taking information, book plots and sometimes the entire book from other people and getting them published under his own name, and then enjoying the credit when they become bestsellers. While most of his victims have become famous writers in their own right, Bradley, in collecting his award, successfully offends all of them. During the party after the award ceremony, Bradley is poisoned and his ex-wife is framed for the crime, who calls in Perry, Della and Ken to investigate.

U.S. Marine David Berman manages to get himself transferred to Paris to search for a hidden Nazi, Krugman, that had killed his grandparents and crippled his mother. He manages to find a witness but just after they talk, she is run over and killed. That night, he is kidnapped by a shadowy organization and told that Krugman is hiding under the new identity of Felix Altmann. David goes to a health spa and meets Altmann, but Altmann is shot and David is framed for the crime. As an old friend of the family, Perry goes to France to help out, but now not only does that involve freeing David, but he must also discover secrets that have been kept hidden for over 45 years and for which certain people are still more than willing to kill.

Terri Knight is one of the biggest superstars in music, but success had come at a cost for her and those close to her. Displaying a diva status has driven a wedge between not only her and her bandmates but with her own manager and husband Jack Barnett. When Terri is murdered in her penthouse by a hired hitman, Jack is immediately suspected of arranging the hit, but his former law professor Perry takes the case. Among the other suspects are Terri's former friend Carla Peters, who started out with her when they were singing in a Supremes-like trio; her ex-husband, who sang with her in a husband-and-wife duo in her early days before she left him, and various others. Ken, meanwhile, goes undercover to get info from a singer who is the only tie to the unknown hitman. In the end, Perry believes the key to the case lies in the claim by all involved that Terri had changed from the sweet person they all knew into somebody different.

Cast: Tim Reid, Alan Rachins, Vanessa Williams, Angela Bassett, Alice Ghostley, Kene Holliday, Nia Peeples^{[5][1]: 40422}

Richard Stuart is a very wealthy man, thanks to his methods of "assisting" certain people to advance in their careers. However, he is blackmailing all of his clients and invites them every now and then to a poker game in Las Vegas, through which he gets his money from them. David Benson's brother was killed thanks to one of Richard's schemes and during one of the "poker" parties, David bursts in with a gun and attempts to shoot Richard but is overpowered and thrown out. Later on that night, Richard is shot with David's gun and David is arrested for the crime. David's young daughter Melanie had followed her father to Las Vegas and when David is arrested runs to Perry who is in town for a boxing match with Ken. Perry knows of Richard's methods and as he wants to know the truth sets out with Della and Ken to solve the mystery but Melanie wants to help too and gets herself in major trouble with one of the suspects.

Perry is at TV station "KGGY" to be interviewed but thanks to the interference of main anchor-person Brett Huston the interview is pulled. Mostly everybody hates Brett as he knows all the station workers' secrets and has also written a memo insulting all of the main station players: Vic St. John, the station manager; Twyla Cooper, the producer; Chuck Gilmore, the sports reporter; Gary Slate, the weatherman; Cassie Woodfield, the reporter; and Gillian Pope. Brett is shot dead with Gillian's gun and therefore she is arrested for the crime. Gillian calls in Perry, Della and Ken to investigate. As Della and Perry set out to solve the mystery, Ken gets close to Cassie but she is a suspect and when it appears that somebody is trying to kill her, the mystery deepens.

With strong reservations, and against the wishes of both Della and especially Ken, Perry agrees to defend former mob figure Johnny Sorrento when he is accused of ordering a hit on his wife, who was threatening to divorce him. With several businesses, including a movie studio, under his watch, Sorrento claims that he is legitimate and that his less-than-reputable past is behind him, but others are less convinced. Perry, meanwhile, has his eye on other suspects, including a restaurateur feeling owed by Johnny, and a mystery woman whose unwarranted advances on Johnny had triggered his wife's jealousy just before her death. Perry soon realizes that finding the real killer may depend on Johnny's estranged son and a previous unsolved murder from years back that Johnny may have been involved in.

Cast: Mason Adams, Paul Anka, Michael Nader, Anne Schedeen, Pamela Bowen, Sean Kanan, Stephen Tobolowsky^{[5][1]: 40658}

Internationally renowned magician David Katz acomes to Denver with his group to perform for a charity gala for disabled children, attended by Perry and Della, who support the charity. His arrogant assistant Kate Ford tells David that she is, from now on, going to do an illusion in which an assistant is raised in a glass coffin only to disappear when the coffin is opened up in the air (while the assistant climbs out before the coffin is raised). After a one night stand with David, Kate is pregnant and blackmails David, who is unable to have children with his wife Judy, creating the rest of the group to vehemently loathe her. At the gala, the glass coffin is raised but when it opens Kate's dead body falls to the ground - strangled.

Dyan Draper, editor of a well-known fashion magazine, is infamous for writing columns that destroy other people's careers; she also drives her employees to near-madness with her orders. Lauren Jeffreys, editor of another magazine, meets with Dyan and tries unsuccessfully to stop Dyan from writing about her in her next column. She tries again at Dyan's place, but Dyan is next seen dead on the floor. Lauren is the prime suspect, but as she's friends with Della and Perry, Perry takes the defense. Lauren gave birth at 16 and the child grew up to be Julia Collier, Dyan's private assistant, and Lauren and Julia try to reunite. Meanwhile, Ken comes up against Albert Nardone, infamous crime mobster and little-known fashion designer, as Nardone's nephew gets killed by Dyan's killer and unwillingly has one of Nardone's hoods "assist" him in searching for the killer.

Recently-deceased painter Truman York turns up alive when paintings supposedly painted by him apparate. He goes to the gallery where they're being sold and slashes them, before going to his dealer to find out where these paintings are coming from. Later, a man whose wife was killed in the accident that he was supposedly killed in shows up looking for him. He goes to his wife and asks her to let him stay in her apartment; later he is killed. The man is arrested and he calls his friend Ken Malansky for help, and Ken calls Perry. Once Perry agrees to solve the case, he finds that his chief suspect is a photographer who may have been looking to cash in on the name of a dead celebrity.

Sleazy talk show host Ted Mayne writes a tell-all book, which enrages and embarrasses several very prominent women. One of them, actress Roxanne Shield, loses her composure during an interview and winds up making a televised death threat. When Ted is latter murdered, she is arrested. Witnesses claim they saw Roxanne outside his apartment that night and police later find the murder weapon in her car. Renowned defence attorney Perry Mason accepts the challenge of defending her in court.

During the wedding ceremony of fashionable pop star Kaitlynn Parrish, a heated altercation between a drunken woman and her father breaks out, disrupting the festivities. When the uncle is found murdered and Parrish is fingered as the suspect, Perry enlists Della and Ken to help him uncover the truth.

Alana Westbrook, a maverick owner of a cosmetics company, is unveiling a new cream which she claims she's been using. Having previously concealed her age, she reveals she is 60 years old, crediting the cream for her youthful appearance. After she is later murdered and the formula goes missing, her husband Arthur is arrested and Perry defends him.

Dr. Sheila Carlin, a radio psychologist and old friend of Della's, asks for Perry's help when she is being pestered by someone. Theorizing that it could be one of her co-workers at the radio station, she arranges for Perry to be interviewed by the station's owner Winslow Keene, whom she suspects of being behind the harassment. Winslow, meanwhile, enrages the rest of the talk show hosts at the station by informing them of changes that he is making to their time slots. That night, Winslow is shot by a hitman hired by someone at the station and Sheila is set up for the murder. Taking on the case with Della and Ken, Perry finds out that Keene's power over the station came from various secrets he had over his stars, including a shock-jock duo, a conspiracy theorist, a former athlete turned sports show host, and a relationship expert. Meanwhile, Ken teams up with an undercover cop as they search for the hired gunman, which might depend on finding a mystery woman from the cop's past.

Cast: Fritz Coleman, Cristina Ferrare, G. Gordon Liddy, Fred Roggin, Montel Williams, Mariette Hartley, Regis Philbin^{[5][1]: 41146}

When Mark Stranton, a popular soap opera actor, dies from an on-camera kiss, which triggered an allergic reaction, Perry's goddaughter Kris Buckner, the victim's co-star who had planted the deadly kiss, is framed. Taking on her defense, Mason finds that nearly the whole show's cast and crew had good reason to kill Stranton, for reasons varying from a publicity stunt involving marriage to one of his co-stars to his role in a staff member's abortion. Meanwhile, Ken, with help from a visiting tourist, finds his life in danger as he and Perry suspect that the clue to Stranton's death might lie in an unsolved 28-year-old murder.

Cast: Stuart Damon, Linda Dano, Genie Francis, Arleen Sorkin, Michael Tylo^{[5][1]: 41218}

Note: This was the last film to be filmed with Raymond Burr prior to his death; it was aired posthumously two and a half months after his passing. An in-memory note for Raymond Burr appeared at the end of the film.

Note: To address the death of Raymond Burr, Perry Mason is addressed as being out of town, or unavailable in general, for the remaining films.

After a photo shoot featuring his exes, fashion photographer David Morrison is blinded by camera flashes and stabbed with a sword. His current wife, Dee who arranged the shoot, is accused of the crime. Beforehand, to oversee legal issues regarding both the shoot and the women involved, Dee had asked for help from a friend of hers, attorney Anthony Caruso, who had overseen each of the exes' divorces. Caruso, borrowing his friend Perry Mason's office while Perry is away, soon goes from overseeing a photo shoot to handling a murder case. With Della and Ken's help, Caruso digs into past secrets of David's marriages, which make all his exes prime suspects.

Starring Paul Sorvino as Anthony Caruso.

Cast: Shelley Hack, Kathy Ireland, Maud Adams, Beverly Johnson, Kim Alexis, Paula Marshall, Eric Braeden^{[5][1]: 41280}

For the remainder of the series, Hal Holbrook takes over as "Wild Bill" McKenzie, a motorcycle-riding ranch owner and former prosecutor, whose reputation in the courtroom has led to a series of colorful stories spread around about him, from him getting a confession by threatening to shoot the accused's dog to, at the movie's start, exposing a corrupt defense attorney working against his own client. When he agrees to fill in for Perry as a guest speaker at a lavish resort, he quickly finds himself coming to the defense of an old friend of his, retired chess star Daniel Kingman. Kingman is accused of murdering trashy tabloid host Adrian Lye, who had proof that Kingman had thrown one of his last matches. As Will Bill, with help from Della and Ken, gets to work, they soon find out Lye had dirt on many of the guests gathered at the hotel, including a basketball team owner, an aging actress, and a has-been director.

Starring Hal Holbrook as "Wild Bill" McKenzie.

Cast: Robin Leach, Dixie Carter, Diahann Carroll, Robert Englund, James Stephens^{[5][1]: 41369}

"Wild Bill" McKenzie had, months earlier, faced tragedy when a friend of his, former D.A. Harlan Richards allegedly committed suicide. Richards, running for governor, had seen his campaign damaged by rumors of his having an affair with Charlotte Moore, an exotic dancer who was seeking hush money. Richards' daughter Karen, is convinced that both the accusations and her father's death were planned and ordered by Harlan's opponent, sitting governor Ryan Allison. Allison, after a fiery confrontation with Karen at his office, invites her to meet with him, claiming that he wants to investigate Harlan's death. Karen arrives that night to find him dead from a stabbing. Taking on her defense, Bill, with the help of his ranch guests Della and Ken, starts digging into motive and soon finds secrets not only among Allison's administration but even from Allison's wife, who already poses a threat to Karen's defense by her claiming to have left her husband alive just minutes before Karen arrived. Added into the mix is not only blackmailer Charlotte Moore, who has been suspiciously missing since the governor's murder, but also local corrupt businessman Johnny Steele, who may have a member of Allison's team on his payroll.

Starring Hal Holbrook as "Wild Bill" McKenzie

Bill McKenzie's niece works as a production assistant for controversial television personality Josie Joplin, who publicly accuses her of having an affair with her husband. One night McKenzie's niece receives a message which she believes is from Josie to go to her hotel room, when she gets there someone knocks her out and when she wakes up, Josie is dead and she's the number one suspect, so McKenzie defends her.

Starring Hal Holbrook as "Wild Bill" McKenzie

Cast: Tony Roberts, Victoria Jackson, David Rasche, Dyan Cannon, Holland Taylor, Tina Yothers^{[5][1]: 41497}