Phenylpyrazole

Phenylpyrazole insecticides

Phenylpyrazole insecticides

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Phenylpyrazole insecticides are a class of chemically-related broad-spectrum insecticides. The chemical structures of these insecticides are characterized by a central pyrazole ring with a phenyl group attached to one of the nitrogen atoms of the pyrazole.

Chemical structure of fipronil, a common phenylpyrazole insecticide

History

Phenylpyrazole insecticides were developed in response to increasing pesticide resistance to other chemicals. Now, along with neonicotinoids, they are some of the most widely-used pesticides.[1]

Mode of Action

Phenylpyrazole insecticides function by blocking glutamate-activated chloride channels in insects. Mammals do not have this type of chloride channel, making them much less susceptible to its effects. However, they do have the capacity to disrupt epithelial cells in the human intestine and adversely impact human health.[1]

Examples

Examples include:

  • acetoprole
  • ethiprole
  • fipronil
  • flufiprole
  • pyraclofos
  • pyrafluprole
  • pyriprole
  • pyrolan
  • vaniliprole

References

  1. [1]
    Vidau, C.; Brunet, J. L.; Badiou, A.; Belzunces, L. P. (2009). "Phenylpyrazole insecticides induce cytotoxicity by altering mechanisms involved in cellular energy supply in the human epithelial cell model Caco-2". Toxicology in Vitro. 23 (4): 589–597. doi:10.1016/j.tiv.2009.01.017.
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This article uses material from the Wikipedia article Phenylpyrazole, and is written by contributors. Text is available under a CC BY-SA 4.0 International License; additional terms may apply. Images, videos and audio are available under their respective licenses.