Phospholipid:diacylglycerol_acyltransferase

Phospholipid:diacylglycerol acyltransferase

Phospholipid:diacylglycerol acyltransferase

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In enzymology, a phospholipid:diacylglycerol acyltransferase (EC 2.3.1.158) is an enzyme that catalyzes the chemical reaction

phospholipid + 1,2-diacylglycerol lysophospholipid + triacylglycerol
Quick Facts Identifiers, EC no. ...
Quick Facts Beta-secretasePhospholipid:diacylglycerol acyltransferase, Identifiers ...

Thus, the two substrates of this enzyme are phospholipid and 1,2-diacylglycerol, whereas its two products are lysophospholipid and triacylglycerol.

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is phospholipid:1,2-diacyl-sn-glycerol O-acyltransferase. This enzyme is also called PDAT. This enzyme participates in glycerolipid metabolism.

An important human protein from this family is lecithin–cholesterol acyltransferase.

References

    • Dahlqvist A, Stahl U, Lenman M, Banas A, Lee M, Sandager L, Ronne H, Stymne S (June 2000). "Phospholipid:diacylglycerol acyltransferase: an enzyme that catalyzes the acyl-CoA-independent formation of triacylglycerol in yeast and plants". Proceedings of the National Academy of Sciences of the United States of America. 97 (12): 6487–92. Bibcode:2000PNAS...97.6487D. doi:10.1073/pnas.120067297. PMC 18631. PMID 10829075.


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