Plasmodium agamae is a parasite of the genus Plasmodium subgenus Sauramoeba. As in all Plasmodium species, it has both vertebrate and insect hosts. The vertebrate host is the rainbow lizard (Agama agama). The vectors are Lutzomyia or Culicoides species.

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Plasmodium agamae
Scientific classification
Domain:	Eukaryota
Clade:	Diaphoretickes
Clade:	SAR
Clade:	Alveolata
Phylum:	Apicomplexa
Class:	Aconoidasida
Order:	Haemospororida
Family:	Plasmodiidae
Genus:	Plasmodium
Species:	P. agamae
Binomial name
Plasmodium agamae Wenyon, 1909

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This species was described by Wenyon in 1909.^{[citation needed]}

The schizonts produce 8 merozoites.^{[citation needed]}

P. agamae is distributed throughout much of Africa.

Host species infected by this parasite include Agama colonorum.^{[citation needed]}

Infection with P. agamae induces anaemia in its host which in turn reduces running stamina. Infection with P. agamae alone does not reduce the number of eggs laid by the females but simultaneous coinfection with P. giganteum may result in a reduction in the clutch size by two thirds.^{[citation needed]}

Fever occurs but is irregular.^{[citation needed]}