Plymouth Drake was a borough constituency in the city of Plymouth, in Devon. It elected one Member of Parliament to the House of Commons of the Parliament of the United Kingdom by the first past the post system of election.

The first Drake constituency was created for the 1918 general election, and abolished for the 1950 general election. For most of this time it was held by the Conservative Party. It was a Labour gain in the Attlee landslide of 1945, although it had been held by Labour once before, in the 1929–31 Parliament.

The second incarnation of the constituency was created for the February 1974 general election. For the whole of its 23-year existence it was represented by just one MP, Dame Janet Fookes of the Conservative Party. It was always a marginal seat during this period, but Dame Janet managed to survive many strong challenges at each general election she fought, including winning with a majority of just 34 in October 1974 – making Drake the most marginal Conservative seat at that election. She served as a Deputy Speaker of the House to Betty Boothroyd from 1992 until she retired from the Commons in 1997.

The constituency was abolished for the 1997 general election, with its wards being transferred to the redrawn constituency of Plymouth Sutton, which was gained by the Labour Party in the Blair landslide of that year. Most of the territory of Drake is now covered by the constituency of Plymouth Sutton and Devonport.

1918–1950: The County Borough of Plymouth wards of Drake, Mount Edgcumbe, Mutley, Pennycross, St Peter, Stoke, and Valletort.

1974–1983: The County Borough of Plymouth wards of Compton, Drake, Honicknowle, Pennycross, Tamerton, Trelawny, and Whitleigh.

1983–1997: The City of Plymouth wards of Compton, Drake, St Peter, Stoke, Sutton, and Trelawny.

In its 1918 and 1983 incarnations the constituency included Plymouth city centre, which was transferred in 1997 to Plymouth Sutton and in 2010 to Plymouth Sutton and Devonport.

• List of parliamentary constituencies in Devon