The Professional Fraternity Association (PFA) is an American association of national, collegiate, professional fraternities and sororities that was formed in 1978. Since PFA groups are discipline-specific, members join while pursuing graduate (law, medicine, etc.) degrees as well as undergraduate (business, engineering, etc.) degrees. PFA groups seek to develop their members professionally in addition to the social development commonly associated with Panhellenic fraternities. Membership requirements of the PFA are broad enough to include groups that do not recruit new members from a single professional discipline. The PFA has welcomed service and honor fraternities as members; however, Greek letter honor societies more commonly belong to the Association of College Honor Societies.

The Professional Panhellenic Association (PPA), for women's groups, was founded in 1925, and the Professional Interfraternity Conference (PIC), for men's groups, was founded in 1928. These groups came about due to rapid growth among all types of fraternities during the late 1920s.

The PFA resulted from the merger of the Professional Interfraternity Conference and the Professional Panhellenic Association in 1978. The merger itself was the result of the impact of Title IX on most fraternal groups with professional affiliations.^[5]

Chartering organizations:

• Alpha Delta Theta – Medical Technology
• Alpha Kappa Psi – Business Administration
• Alpha Rho Chi – Architecture
• Alpha Tau Delta – Nursing
• Alpha Chi Sigma – Chemistry
• Alpha Omega – Dentistry
• Delta Epsilon Mu – Pre-health
• Delta Theta Phi – Law
• Delta Omicron – Music
• Delta Sigma Delta – Dentistry
• Delta Sigma Pi – Business Administration
• Delta Psi Kappa – Physical Education
• Zeta Phi Eta – Communication Arts and Sciences
• Kappa Beta Pi – Law
• Kappa Delta Epsilon – Education
• Kappa Epsilon – Pharmacy
• Kappa Psi – Pharmacy
• Lambda Kappa Sigma – Pharmacy
• Mu Phi Epsilon – Music
• Xi Psi Phi – Dentistry
• Rho Pi Phi – Pharmacy
• Sigma Alpha Iota – Music
• Sigma Delta Kappa – Law
• Sigma Phi Delta – Engineering
• Phi Alpha Delta – Law
• Phi Beta – Music, Speech, Drama and Dance
• Phi Beta Pi-Theta Kappa Psi – Medical
• Phi Gamma Nu – Business
• Phi Delta Epsilon – Medical
• Phi Mu Alpha Sinfonia – Music
• Phi Rho Sigma – Medicine
• Phi Chi – Medicine
• Phi Chi Theta – Business and Economics
• Psi Omega – Dentistry
• Omega Tau Sigma – Veterinary Medicine

Current membership of active members as of June 25, 2019.^[6]

This includes the member organizations of the two former groups (PIC, PPA) that merged to form the PFA and organizations not currently active within the PFA.^[6][23][24]

• Note 1: PIC Charterer indicates participation in the "Preparatory Conference" at the Hamilton Hotel, Washington, D.C., on March 2 and 3, 1928.^{[1]: 13 [44]}
• Note 2: PPA Charterer indicates ratification of the provisional constitution of the PPA by the Second Annual Conference on November 26, 1926.^[1]: 14
• Note 3: PFA Charterer indicates membership in good standing in the PPA or PIC at the time of the merger and thus by the agreement of the joint conference in October 1977, charter members.^{[23][1]: 15}
• Note 4: Membership in 1968 only included in notes if group was not a charterer for both PPA/PIC and PFA.