Proheptazine

Proheptazine

Proheptazine

Opioid analgesic drug

Proheptazine is an opioid analgesic related to pethidine. It was invented in the 1960s.[2]

Quick Facts Clinical data, ATC code ...

Proheptazine produces similar effects to other opioids,[3] including analgesia, sedation, euphoria, dizziness and nausea.

In the United States it is a Schedule I Narcotic controlled substance with an ACSCN of 9643 and a 2013 annual aggregate manufacturing quota of zero. The salts in use are the citrate (free base conversion ratio 0.589), hydrobromide (0.773), and hydrochloride (0.883).[4][5]

References

  1. [1]
    Anvisa (2023-03-31). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 2023-04-04). Archived from the original on 2023-08-03. Retrieved 2023-08-16.
  2. [2]
    Diamond J, Bruce WF, Tyson FT (January 1964). "Synthesis and Properties of the Analgesic DL-α-1,3-dimethyl-4-phenyl-4-propionoxyazacycloheptane (Proheptazine)". Journal of Medicinal Chemistry. 7: 57–60. doi:10.1021/jm00331a013. PMID 14186026.
  3. [3]
    Finney ZG, Riley TN. 4-Anilidopiperidine analgesics. 3. 1-Substituted 4-(propananilido)perhydroazepines as ring-expanded analogues. J Med Chem. 1980 Aug;23(8):895-9. doi:10.1021/jm00182a016 PMID 7190616
  4. [4]
    "Quotas - 2014". Diversion Control Division. Drug Enforcement Agency, U.S. Department of Justice.
  5. [5]
    "Conversion Factors for Controlled Substances". Diversion Control Division. Drug Enforcement Agency, U.S. Department of Justice.



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